疑难病杂志2024，Vol.23Issue(7)：793-797,5.DOI:10.3969/j.issn.1671-6450.2024.07.006
宫颈癌患者自身免疫功能、肿瘤标志物水平对癌肿根治术后复发的影响
Effects of autoimmune function and tumor markers on recurrence after radical operation in patients with cervical cancer
摘要
Abstract
Objective To investigate the effects of autoimmune function and tumor markers on recurrence after radical resection in patients with cervical cancer.Methods We conducted a study involving 108 patients diagnosed with cervical cancer who received treatment at our hospital between January 2021 and November 2022.All patients underwent radical resection for cervical cancer.Based on the occurrence of recurrence and metastasis within 1 year after treatment initi-ation,the patients were categorized into two groups:non-recurrent group(n=86)and recurrent group(n=22).The differ-ences of clinical data,disease characteristics,autoimmune function and tumor markers of cervical cancer between the two groups were compared.Spearman correlation analysis and multivariate logistic regression analysis were employed to identify the risk factors for tumor recurrence in patients with cervical cancer.Furthermore,the predictive value of these risk factors in postoperative recurrence of cervical cancer was evaluated using receiver operating characteristic curve(ROC)analysis.Re-sults In the recurring cohort,there was a notable increase in the proportion of patients displaying vascular tumor thrombus and deep muscular invasion(x2/P=4.923/0.027,4/284/0.038).Additionally,there was a significant decrease in the average CD4+T/CD8+T ratio and the proportion of NK cells(t/P=4.117/＜0.001,2.680/0.009,3.708/＜0.001).Conversely,the average SII level and the average CA125 and CA199 levels were markedly elevated(t/P=2.040/0.044,2.586/0.011).Through Spearman correlation analysis and multivariate Logistic regression analysis,it was determined that a lower CD4+T/CD8+T ratio,NK cell ratio,and higher SII and CA125 levels were identified as risk factors for postoperative recurrence in cervical cancer patients[OR(95％CI)=0.019(0.010-0.048),0.621(0.453-0.852),1.080(1.003-1.160),1.042(1.009-1.076)].Moreo-ver,ROC analysis demonstrated that the CD4+T/CD8+T ratio,NK cell ratio,SII,and CA125 independently and collectively provided higher predictive value in the prognosis of postoperative recurrence in cervical cancer patients(Z/P=4.234/＜0.001,5.113/＜0.001,4.512/＜0.001,5.452/＜0.001).Conclusion Patients who have undergone radical resection for cervical cancer face a daunting challenge,as their compromised immune system and elevated levels of tumor markers highlight the potential for recurrence.Proper surveillance of immune function and prompt intervention can effectively reduce the likelihood of tumor recurrence after surgery,ultimately leading to a more favorable prognosis for these patients.关键词
宫颈癌/癌肿根治术/免疫功能/肿瘤标志物/复发Key words
Cervical cancer/Radical operation/Immune function/Tumor markers/Tumor recurrence分类
临床医学引用本文复制引用
克热曼·牙库甫,玛丽亚木古丽·克依木,韩涛,苏莱娅·胡赛音..宫颈癌患者自身免疫功能、肿瘤标志物水平对癌肿根治术后复发的影响[J].疑难病杂志,2024,23(7):793-797,5.基金项目
新疆维吾尔自治区自然科学基金项目(2021D01C194) Natural Science Foundation in Xinjiang Uygur Autonomous Region(2021D01C194) （2021D01C194）
