云南化工2024，Vol.51Issue(7)：114-117,4.DOI:10.3969/j.issn.1004-275X.2024.07.26
顶空毛细管气相色谱法测定龙胆泻肝片中残留溶剂
Determination of Residual Solvents in LongdanXiegan Tablets by Headspace Capillary Gas Chromatography
尹兴章 1谭冬梅 2张远溪 3赵一丁 3杨深应 1王健芬1
作者信息
- 1. 保山市食品药品检验检测中心,云南 保山 678000
- 2. 云南经济管理学院,云南 昆明 650000
- 3. 保山中医药高等专科学校,云南 保山 678000
- 折叠
摘要
Abstract
(Objective)The aim is to establish a new method to determine the organic solvent residues of methanol and ethanol in Longdan Xiegan tablets.(Methods)Headspace capillary gas chromatography was used,and the column was an Agilent DB-624 capillary column(30 m×ϕ0.53 mm,3 μm);the detection conditions were:programmed temperature rise;inlet temperature was 220℃;detector(FID)temperature was 250℃;split injection,5∶1 split ratio was selected;headspace vial equilibration temperature was 85℃,equilibration time was 20 min.(Results)The two organic solvents,methanol and ethanol,were well separated with good linearity in the ranges of 1.0335～248.04 μg·mL-1(r=0.9997)and 1.0505～252.12 μg·mL-1(r=0.9996),respectively,and the average recoveries were 97.4%(RSD=1.7%,n=6),95.7%(RSD=1.6%,n=6).(Conclusion)The method has good repeatability,precision and recovery,and is simple,sensitive and selec-tive,which can provide a reference basis for the quality control of residual solvents of gentian diarrhea liver tablets.关键词
龙胆泻肝片/甲醇/乙醇/残留溶剂/顶空毛细管色谱法Key words
Longdan Xiegan Tablet/Methanol/Ethanol/Residual Solvent/Headspace Capillary Gas Chromatography分类
化学化工引用本文复制引用
尹兴章,谭冬梅,张远溪,赵一丁,杨深应,王健芬..顶空毛细管气相色谱法测定龙胆泻肝片中残留溶剂[J].云南化工,2024,51(7):114-117,4.
