医学信息2024，Vol.37Issue(14)：96-99,4.DOI:10.3969/j.issn.1006-1959.2024.14.018
SAA、IL-6、C3、C4联合检测对SLE患者的诊断价值
Diagnostic Value of Combined Detection of SA A,IL-6,C3 and C4 in SLE Patients
摘要
Abstract
Objective To investigate the correlation and risk factors of SAA,IL-6,C3 and C4 in patients with SLE.Methods From October 2020 to May 2023,110 patients with SLE inthe First People's Hospital of Yulin and 80 healthy people in the same period were selected as the research objects.The levels of SAA,IL-6,C3 and C4 in the two groups were compared,as well as the diagnostic value of index detection.Results Compared with the control group,the levels of SAA,IL-6 in the SLE group were increased,while the levels of C3 and C4 in the SLE group were decreased,and the differences were statistically significant(P＜0.05).The results of ROC curve analysis showed that the AUC of C3 was the largest(AUC=0.916).The AUC of SAA+IL-6 was the largest(AUC=0.920).Binary Logistic regression analysis showed that SAA and IL-6 were risk factors for SLE patients,while C3 was a protective factor for SLE patients.Spearman correlation analysis showed that SAA was positively correlated with IL-6,SAA and IL-6 were negatively correlated with C3 and C4,respectively.Conclusion The combination of SAA,IL-6,C3,C4 detection and comprehensive evaluation of the correlation has important reference value for the diagnosis,treatment and prognosis of SLE.关键词
血清淀粉样蛋白A/白介素6/补体/系统性红斑狼疮Key words
Serum amyloid protein A/Interleukin 6/Complement/Systemic lupus erythematosus分类
医药卫生引用本文复制引用
梁敏敏,邹光美,杨小兰,吴声楹,吴博文..SAA、IL-6、C3、C4联合检测对SLE患者的诊断价值[J].医学信息,2024,37(14):96-99,4.基金项目
1.玉林市科学研究与技术开发计划课题(编号:玉市科20204402) （编号:玉市科20204402）
2.广西壮族自治区卫生健康委员会自筹经费科研课题(编号:Z20211083) （编号:Z20211083）
