应用化学2024，Vol.41Issue(6)：861-869,9.DOI:10.19894/j.issn.1000-0518.230359
pH响应型磁性纳米复合材料的合成及其载药性能
Synthesis and Drug Loading Performance of pH-Responsive Magnetic Nanocomposites
摘要
Abstract
Mesoporous silica-coated magnetic nanoparticles were prepared using a modified Stöber method,followed by amino-functionalization treatment on the material surface through grafting to form NH2-MMNPs.A safe and non-toxic oxidized pullulan was used as the gated material,forming a pH-responsive imine bond between the amino groups on the surface of the nanomaterial and the aldehyde groups of oxidized pullulan,thus creating a gated switch.The loaded doxorubicin hydrochloride was encapsulated to form the intelligent drug delivery system(oMMNPs/DOX).The structure,properties,and morphology of the composite material were characterized by transmission electron microscopy(TEM),X-ray diffraction spectroscopy(XRD),fourier transform infrared spectroscopy(FT-IR),nitrogen adsorption desorption(BET)and vibrating sample magnetometry(VSM).The results showed that the composite material had good morphology,monodispersity,and superparamagnetism.Drug loading and release experiments indicated a drug loading capacity of 51.65％for NH2-MMNPs;oMMNPs/DOX exhibited pH-responsive drug release behavior and sustained drug release during the release process.Cytotoxicity and fluorescence imaging experiments demonstrated that the composite material had good biocompatibility,successfully loaded drugs,and were uptaken by cells.关键词
氧化普鲁兰/磁性纳米粒子/介孔硅/pH响应/阿霉素Key words
Pullulan oxide/Magnetic nanoparticles/Mesoporous silica/pH response/Doxorubicin分类
化学化工引用本文复制引用
王灵晓,高杉,韦皖豫,李宁波,乔洁,董川..pH响应型磁性纳米复合材料的合成及其载药性能[J].应用化学,2024,41(6):861-869,9.基金项目
太原工业学院青年基金(No.2020LG02)、山西省省筹资金资助回国留学人员科研项目(No.2021-077)和山西省自然科学基金(No.202203021211240)资助 Supported by the Youth Foundation of Taiyuan Institute of Technology(No.2020LG02),Shanxi Scholarship Council of China(No.2021-077)and the Natural Science Foundation of Shanxi Province of China(No.202203021211240) （No.2020LG02）
