中风与神经疾病杂志2024，Vol.41Issue(7)：626-630,5.DOI:10.19845/j.cnki.zfysjjbzz.2024.0121
酒精中毒大鼠小脑损伤的病理改变
Pathological changes of cerebellar injury in rats with alcoholism
赵丽 1关继奎 1陈嘉峰2
作者信息
- 1. 芜湖市第一人民医院,安徽 芜湖 241000
- 2. 吉林大学白求恩第一医院神经内科,吉林 长春 130021
- 折叠
摘要
Abstract
Objective To observe the pathological changes of cerebellar injury in rats with alcoholism.Methods An animal model of chronic alcoholism was established in Wistar male rats by gavage of 50%edible alcohol at increasing doses for 4 weeks.The pathological changes of cerebellar injury in rats after alcoholism were observed using an optical mi-croscope and a transmission electron microscope.Results Optical microscopy in rats with alcoholism showed signifi-cantly reduced number of granule cells and Purkinje cells in the cerebellum,and significant cell degeneration,especially in Purkinje cells.Electron microscopy showed significantly reduced organelles,irregularly shaped nucleus,and unobvi-ous and irregularly shaped nucleolus in cerebellar capillary endothelial cells.Conclusion Alcoholism induces damages to the cerebellar cells and their ultrastructure,providing a basic theoretical basis for the resulting motor and cognitive dys-function.关键词
酒精中毒/小脑损伤/病理改变Key words
Alcoholism/Cerebellar injury/Pathological change分类
医药卫生引用本文复制引用
赵丽,关继奎,陈嘉峰..酒精中毒大鼠小脑损伤的病理改变[J].中风与神经疾病杂志,2024,41(7):626-630,5.
