中风与神经疾病杂志2024，Vol.41Issue(7)：651-654,4.DOI:10.19845/j.cnki.zfysjjbzz.2024.0126
长期服用托吡酯诱发高氯血症伴频发癫痫1例报告并文献复习
Hyperchloraemia with frequent seizures caused by long-term use of topiramate:a case report and literature re-view
何菲 1张高瓒 1漆栋梁 2王立娜 3王立波1
作者信息
- 1. 吉林大学中日联谊医院神经内科,吉林 长春 130000
- 2. 岷县中医院,甘肃 定西 743000
- 3. 吉林省前卫医院急诊科,吉林长春 130000
- 折叠
摘要
Abstract
We report a patient who had topiramate use for 4 years to control epilepsy but was repeatedly hospitalized due to frequent seizures since the second year of the treatment,without triggers such as drug withdrawal,drug reduction,irregular treatment,and irregular lifestyles.Intermittent monitoring of ions revealed electrolyte disorders-hyperchlorae-mia,but symptomatic electrolyte correction was always ineffective.After discontinuing topiramate,blood chlorine quickly returned to normal,and epilepsy was successfully controlled.Based on related literature,we further discuss the possible mechanisms of topiramate-induced hyperchloraemia and frequent seizures,aiming to improve the safety of topiramate in clinical application.关键词
托吡酯/高氯血症/作用机制/癫痫Key words
Topiramate/Hyperchloraemia/Mechanism of action/Epilepsy分类
医药卫生引用本文复制引用
何菲,张高瓒,漆栋梁,王立娜,王立波..长期服用托吡酯诱发高氯血症伴频发癫痫1例报告并文献复习[J].中风与神经疾病杂志,2024,41(7):651-654,4.
