鹿茸多肽对顺铂所致卵巢早衰大鼠卵巢功能的保护作用及其机制OA北大核心CSTPCD
Protective effect of velvet antler polypeptide on ovarian function in cispla-tin-induced premature ovarian failure rats and its mechanism
目的:探讨鹿茸多肽(VAP)对顺铂(DDP)致卵巢早衰模型大鼠的影响及机制.方法:取动情周期正常的雌性大鼠并将其随机分为对照组、模型组、VAP干预组,每组各10只.模型组和VAP干预组通过连续20 d腹腔注射DDP(4 mg·kg-1·d-1)建立卵巢早衰大鼠模型,干预组同时连续20 d灌胃VAP(400 mg·kg-1·d-1).HE染色观察卵巢形态学表现,并对各级发育卵泡计数.ELISA检测血清雌二醇(E2)、促卵泡生成素(FSH)、抗穆勒管…查看全部>>
AIM:To investigate the effect and mechanism of velvet antler polypeptide(VAP)on premature ovarian failure induced by cisplatin(DDP)in rats.METHODS:Female rats with normal estrous cycle were randomly di-vided into the control,model,and VAP groups,with 10 rats in each group.Premature ovarian failure was induced in the model and VAP groups by intraperitoneal injection of DDP(4 mg·kg-1·d-1)for 20 consecutive days,and the VAP group was treated with VAP(400 mg·kg-…查看全部>>
史松;苏比努尔·买买提;尼比热·阿布都瓦依提;杨静;易金玲
新疆医科大学第五附属医院办公室,新疆 乌鲁木齐 830000新疆医科大学第五附属医院妇科,新疆 乌鲁木齐 830000新疆医科大学第五附属医院妇科,新疆 乌鲁木齐 830000新疆医科大学第五附属医院妇科,新疆 乌鲁木齐 830000新疆医科大学第五附属医院妇科,新疆 乌鲁木齐 830000
基础医学
鹿茸多肽顺铂卵巢早衰脂质过氧化铁死亡
velvet antler polypeptidecisplatinpremature ovarian failurelipid peroxidationferroptosis
《中国病理生理杂志》 2024 (7)
1300-1306,7
新疆维吾尔自治区科技支疆项目(No.2020E02129)
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