中国病理生理杂志2024，Vol.40Issue(7)：1316-1323,8.DOI:10.3969/j.issn.1000-4718.2024.07.021
内质网应激在妊娠期糖尿病中的作用及生物活性成分防治的研究进展
Preventive and intervention effect of bioactive compounds on gestational diabetes mellitus based on endoplasmic reticulum stress pathway
摘要
Abstract
The global prevalence of gestational diabetes mellitus(GDM)is approximately 13.4%and is ex-pected to increase annually.However,the precise mechanism behind GDM remains to be established.Increasing evi-dence suggests that insulin resistance(IR)and β-cell impairment are key factors in the pathogenesis of GDM.Endoplas-mic reticulum stress(ERS)is characterized by the activation of the unfolded protein response through three key endoplas-mic reticulum transmembrane proteins:protein kinase RNA-like endoplasmic reticulum kinase(PERK),inositol-requiring enzyme 1α(IRE1α),and activating transcription factor 6(ATF6).ERS is implicated in IR in adipose tissue,liver,skeletal muscle,and placenta,and also plays a crucial role in β-cell impairment through processes such as apopto-sis,pyroptosis,and autophagy.Therefore,targeting ERS could be a potential therapeutic approach for the prevention and treatment of GDM.This review explores the potential role of ERS in IR and β-cell dysfunction in GDM,and provides evi-dence for the preventive and intervention effects of bioactive compounds on GDM based on the ERS pathway.This aims to enhance our understanding of the molecular pathological basis of GDM and offer new strategies for its prevention and treat-ment.关键词
妊娠期糖尿病/内质网应激/胰岛素抵抗/β细胞损伤/生物活性成分Key words
gestational diabetes mellitus/endoplasmic reticulum stress/insulin resistance/β-cell impair-ment/bioactive compounds分类
医药卫生引用本文复制引用
胡楠楠,赵成奥,高芹,翟庆峰..内质网应激在妊娠期糖尿病中的作用及生物活性成分防治的研究进展[J].中国病理生理杂志,2024,40(7):1316-1323,8.基金项目
国家自然科学基金资助项目(No.82204031) （No.82204031）
山东省自然科学基金资助项目(No.ZR2021QH188) （No.ZR2021QH188）
济宁医学院贺林院士新医学临床转化工作站科研基金资助项目(No.JYHL2022MS13) （No.JYHL2022MS13）
