中国病理生理杂志2024，Vol.40Issue(7)：1331-1337,7.DOI:10.3969/j.issn.1000-4718.2024.07.023
lncRNA在肌少-骨质疏松症中作用机制的研究进展
Progress in mechanism of lncRNA in osteo-sarcopenia
摘要
Abstract
Osteoporosis due to muscle deficiency refers to the simultaneous occurrence of metabolic attenua-tion lesions in both skeletal muscle and bone.The occurrence and development of this disease involve a complex regulato-ry network of multiple factors and genes.Long noncoding RNA(lncRNA),as an important class of noncoding RNA mole-cules,plays an important regulatory role in regulating the expression of functional genes.Due to the fact that lncRNA can also affect the metabolism and reconstruction of muscle and skeletal systems by simultaneously regulating the proliferation,differentiation,death,and interaction of muscle and bone cells,they can become a new mechanism and target for improv-ing sarcopenia osteoporosis.关键词
肌少-骨质疏松症/长链非编码RNA/肌骨串扰Key words
osteo-sarcopenia/long noncoding RNA/muscle-bone crosstalk分类
医药卫生引用本文复制引用
刘晏东,邓强,彭冉东..lncRNA在肌少-骨质疏松症中作用机制的研究进展[J].中国病理生理杂志,2024,40(7):1331-1337,7.基金项目
国家中医药管理局国家中医临床研究基地业务建设科研专项课题项目(No.JDZX2015039) （No.JDZX2015039）
甘肃省联合科研基金项目(No.23JRRA1534) （No.23JRRA1534）
兰州市科技计划项目(No.2022-3-30) （No.2022-3-30）
