中国草食动物科学2024，Vol.44Issue(4)：77-81,87,6.DOI:10.3969/j.issn.2095-3887.2024.00.056
截短侧耳素衍生物PCI对48株牛源耐甲氧西林金黄色葡萄球菌临床菌株的抗菌活性
Antibacterial Activity of Pleuromutilin Derivative PCI Against 48 Clinical Isolates of Bovine Methicillin-resistant Staphylococcus Aureus
摘要
Abstract
In order to investigate in vitro and in vivo antibacterial activity of the truncated pleuromutilin derivative PCI against 48 clinical strains of methicillin-resistant Staphylococcus aureus in bovine mastitis,the minimal inhibitory con-centration(MIC)of PCI against Staphylococcus aureus,methicillin-resistant Staphylococcus aureus(MRSA)standard strains,and 48 clinical strains of methicillin-resistant Staphylococcus aureus in bovine mastitis were determined by micro-broth dilution method,and the thigh infection experiment in mice was carried out.The results showed that the MIC of PCI against S.aureus and MRSA was 0.007 8µg/mL,and the MIC of PCI against bovine MRSA clinical strains was 0.007 8-0.125µg/mL.The results of thigh infection in mice showed that PCI reduced the degeneration and necro-sis of muscle tissue,and the amount of bacteria in thigh tissue was significantly lower than that in the tiamulin fumarate group(P＜0.05),which was significantly lower than that in the model group(P＜0.000 1).In summary,PCI has excellent antibacterial activity against 48 clinical isolates of methicillin-resistant Staphylococcus aureus in bovine mastitis,which can alleviate thigh muscle infections caused by MRSA.关键词
截短侧耳素衍生物PCI/牛乳腺炎/耐甲氧西林金黄色葡萄球菌Key words
pleuromutilin derivative PCI/bovine mastitis/methicillin-resistant Staphylococcus aureus分类
农业科技引用本文复制引用
马丹倩,张贺超,齐显龙,李剑勇,李准..截短侧耳素衍生物PCI对48株牛源耐甲氧西林金黄色葡萄球菌临床菌株的抗菌活性[J].中国草食动物科学,2024,44(4):77-81,87,6.基金项目
中国农业科学院科技创新工程(25-LZIHPS-02) （25-LZIHPS-02）
