中国感染控制杂志2024，Vol.23Issue(7)：847-851,5.DOI:10.12138/j.issn.1671-9638.20244933
2018-2022年重庆市复治肺结核患者利福平耐药情况及影响因素
Rifampicin resistance and its influencing factors in re-treated pulmonary tuberculosis patients in Chongqing City from 2018 to 2022
摘要
Abstract
Objective To analyze the status and influencing factors of rifampicin resistance in re-treated pulmonary tuberculosis(PTB)patients registered in Chongqing City,and provide basis for the prevention and control of drug-resistant tuberculosis in this city.Methods Descriptive epidemiological method was adopted to analyze the status of rifampicin resistance in re-treated PTB patients registered in districts and counties of Chongqing City from 2018 to 2022.Chi-square test and binary logistic regression were used to analyze the influencing factors for the status of ri-fampicin resistance in re-treated PTB patients.Results The detection rate of rifampicin resistance in re-treated PTB patients in districts and counties of Chongqing City from 2018 to 2022 was 14.45％(558/3 862),presenting an overall downward trend(x2trend=22.739,P＜0.001).Univariate analysis showed that among re-treated PTB pa-tients,the detection rate of rifampicin resistance was the highest among migrant population,residents in urban areas,workers,and migrant workers(all P＜0.05);rifampicin resistance decreased with the increase of age(Ptrend＜0.001).Multivariate logistic regression analysis showed that the risk of rifampicin resistance gradually decreased with the increase of age;OR value decreased from 2.778 in the＜25 year old group to 1.654 in the ≥45 year old group(all P＜0.001).The risk factors for rifampicin resistance in re-treated PTB patients were migrant popula-tion,residents in urban areas,workers,and migrant workers,with statistically significant differences(all P＜0.05).Conclusion Although the detection rate of rifampicin resistance in re-treated PTB patients in Chongqing has been decreasing year by year,the situation is still severe,and special attention should be paid to the migrant popula-tion,young population,population in the main urban areas,and migrant workers.关键词
复治肺结核/利福平耐药/影响因素Key words
re-treatment of pulmonary tuberculosis/rifampicin resistance/influencing factor分类
医药卫生引用本文复制引用
雷蓉蓉,陈健,石林,余雅..2018-2022年重庆市复治肺结核患者利福平耐药情况及影响因素[J].中国感染控制杂志,2024,23(7):847-851,5.基金项目
重庆市首批公共卫生重点学科(专科)项目 （专科）
重庆市科卫联合医学科研项目(2023MSXM143) （2023MSXM143）
