中国感染控制杂志2024，Vol.23Issue(7)：910-917,8.DOI:10.12138/j.issn.1671-9638.20245387
产气荚膜梭菌毒素疫苗研究进展
Research progress in Clostridium perfringens toxin vaccines
摘要
Abstract
Clostridium perfringens is an important foodborne pathogen that causes intestinal infections and tissue necrosis in both human and animals.A variety of exotoxins it produces are lethal.The increasing demand for ratio-nal use of antimicrobial agents and healthy farming make the implementation of vaccination critically important.H owever,traditional Clostridium perfringens exotoxin vaccines may have problems such as inconsistent efficacy,residual toxins and formaldehyde,raising concerns about the safety of these vaccines.This article systematically in-troduces the latest research progress in traditional toxoid vaccine,genetically engineered recombinant vaccines,and epitope peptide vaccines designed based on reverse vaccinology and immunoinformatics for Clostridium perfringens,providing new ideas for the development and preparation of effective and safe novel Clostridium perfringens toxin vaccines.关键词
产气荚膜梭菌/毒素/流行病学/类毒素疫苗/重组疫苗Key words
Clostridium perfringens/toxin/epidemiology/toxoid vaccine/recombinant vaccine分类
医药卫生引用本文复制引用
王东,张思雨,丁雅文,曾瑾..产气荚膜梭菌毒素疫苗研究进展[J].中国感染控制杂志,2024,23(7):910-917,8.基金项目
国家自然科学基金项目(32360882) （32360882）
宁夏回族自治区重点研发计划重点项目(2023BCF01038) （2023BCF01038）
宁夏自然科学基金重点项目(2022AAC02019) （2022AAC02019）
