中国临床药理学杂志2024，Vol.40Issue(13)：1968-1971,4.DOI:10.13699/j.cnki.1001-6821.2024.13.025
分泌性磷酸蛋白SPP1在多种肿瘤的免疫浸润相关性分析
Immunoinfiltration correlation analysis of secreted phosphoprotein SPP1 in multiple tumors
摘要
Abstract
Objective To utilize bioinformatic approaches to elucidate the correlation between secreted phosphoprotein 1(SPP1)and immune infiltration in various malignancies,elucidating the mechanism of gene function in cancer-immune cell interplay.Methods Cancer samples were derived from the Cancer Genome Atlas(TCGA)and Genotype-tissue Expression(GTEx)database,examining SPP1 expression difference between tumors and normal tissues using Gene Expression Profiling Interactive Analysis(GEPIA2),and its correlation with different immune cells in extracellular matrix via TIMER2 Database.SPP1's association with interacting molecules was scrutinized on the STRING website,followed by assessment of its distinct functional state across various cancers from Cancer Single-cell State Atlas Database(Cancer SEA).Results In 32 tumor types,SPP1 mRNA is significantly elevated in 23 types of cancers and correlates heavily with fibroblast,integrin family,and CD44.Furthermore,the SPP1 gene exhibits profound specificity in tumor functions such as vascular invasion,metastasis,DNA damage,and repair.Conclusion Specific expression of SPP1 in tumors signifies a significant correlation with tumor immune cells in the extracellular matrix,promoting tumor progression and invasion.This suggests that targeted monitoring of SPP1 could serve as a prospective cancer diagnostics/therapeutics biomarker.关键词
分泌性磷酸蛋白1/巨噬细胞/免疫浸润/细胞外基质/泛癌分析Key words
secreted phosphoprotein 1/macrophage/immunoinfiltration/extracellular matrix/pan-cancer analysis分类
医药卫生引用本文复制引用
陈洁,陈琳,谷延伦,张默,门展宇,汪露,庞晓丛..分泌性磷酸蛋白SPP1在多种肿瘤的免疫浸润相关性分析[J].中国临床药理学杂志,2024,40(13):1968-1971,4.基金项目
国家重点研发计划基金资助项目(2020YFC2008304) （2020YFC2008304）
国家自然科学基金面上资助项目(82274015) （82274015）
