中国临床药理学杂志2024，Vol.40Issue(13)：1972-1976,5.DOI:10.13699/j.cnki.1001-6821.2024.13.026
Wnt5a-Frizzled-2通路与缺血再灌注损伤的研究现状
Research status of Wnt5a-Frizzled-2 pathway and ischemia-reperfusion injury
摘要
Abstract
The Wnt signaling pathway includes both classical and non classical pathways,Wnt5a-Frizzled-2 pathway participates in the Wnt/Ca2+signaling pathway in the non-classical pathway,which is activated by the Wnt-related protein Wnt5a and its ligand Frizzled-2.It can regulate some key sites in cells to affect cell signal transduction,and is closely related to cell growth process.Activation of Wnt5a-Fizzled-2 pathway occurs in some tissues with abundant blood supply,such as heart and brain tissues,during ischemia-reperfusion.Activation of the Wnt5a-Frizzled-2 pathway causes these intracellular calcium overload,ultimately promoting apoptosis.This article reviews the abnormal activation of Wnt5a-Frizzled-2 signaling pathway in ischemia-reperfusion injury diseases and the induced calcium overload leading to apoptosis,in order to provide reference for the study of physiological mechanisms of ischemia-reperfusion injury.关键词
Wnt5a-跨膜蛋白受体2通路/细胞凋亡/细胞自噬/缺血再灌注损伤Key words
Wnt5 a-Frizzled-2/cell apoptosis/autophagy/ischemia-reperfusion injury分类
医药卫生引用本文复制引用
孙志鹏,董树素,马川程,王琛莹,陈飞,王海英..Wnt5a-Frizzled-2通路与缺血再灌注损伤的研究现状[J].中国临床药理学杂志,2024,40(13):1972-1976,5.基金项目
国家自然科学基金青年基金资助项目(81703490) （81703490）
山东省医药卫生科技发展计划基金资助项目(202002061311) （202002061311）
济宁医学院教师科研扶持基金资助项目(JYFC2019KJ013) （JYFC2019KJ013）
济宁医学院大学生创新训练计划基金资助项目(cx2021140) （cx2021140）
