中国临床药理学杂志2024，Vol.40Issue(14)：2018-2022,5.DOI:10.13699/j.cnki.1001-6821.2024.14.004
克林霉素磷酸酯凝胶联合光动力疗法治疗玫瑰痤疮患者的临床研究
Clinical trial of clindamycin phosphate gel combined with photodynamic therapy in the treatment of patients with acne rosacea
摘要
Abstract
Objective To observe the effect and safety of clindamycin phosphate gel combined with photodynamic therapy in the treatment of acne rosacea.Methods Patients with acne rosacea were divided into treatment group and control group by random number table method.The control group was treated with external application of clindamycin phosphate gel twice a day for 4 weeks.The treatment group was given 5-aminolevulinic acid photodynamic therapy on this basis,once a week for 4 weeks.The clinical efficacy of the two groups was evaluated.The erythema,papulopustule,demodex folliculorum and quality of life[dermatology life quality index(DLQI)]of the two groups were compared after 2 weeks and 4 weeks of treatment.The recurrence status was followed up and the safety of the treatment regimen was evaluated.Results There were 70 cases in treatment group and 70 cases in control group.The total clinical effective rate after 4 weeks of treatment in treatment group was 87.14％,which was higher than 72.86％in control group(P＜0.05).After 2 weeks of treatment,the erythema scores in treatment group and control group were(2.14±0.57)and(2.63±0.52)points;the papulopustule scores were(2.28±0.46)and(2.56±0.49)points;the total counts of demodex folliculorum of(2 mm ×2 mm)were 10.12±3.55 and 11.74±4.31;DLQI scores were(11.27±2.49)and(12.57±2.28)points.After 4 weeks of treatment,the erythema scores in treatment group and control group were(1.16±0.32)and(1.59±0.38)points;the papulopustule scores were(0.92±0.27)and(1.37±0.41)points;the total counts of demodex folliculorum of(2 mm ×2 mm)were 6.08±2.39 and 8.69±2.47;and the DLQI scores were(5.09±1.22)and(6.88±2.16)points,all with significant difference(all P＜0.05).During treatment,there was no statistical significance in the incidence of adverse drug reactions between treatment group and control group(28.57％vs 18.57％,P＞0.05).Follow-up to 3 months after the end of treatment,the recurrence rates in treatment group and control group were 4.29％and 14.29％,with statistical difference(P＜0.05).Conclusion Clindamycin phosphate gel combined with photodynamic therapy has an exact efficacy in the treatment of acne rosacea,and it has obvious advantages in relieving symptoms,improving demodex folliculorum infection and enhancing quality of life of patients,and it does not increase the incidence of adverse drug reactions.关键词
克林霉素磷酸酯凝胶/光动力疗法/玫瑰痤疮/毛囊蠕形螨感染Key words
clindamycin phosphate gel/photodynamic therapy/acne rosacea/demodex folliculorum infection分类
医药卫生引用本文复制引用
宋红娟,张鑫..克林霉素磷酸酯凝胶联合光动力疗法治疗玫瑰痤疮患者的临床研究[J].中国临床药理学杂志,2024,40(14):2018-2022,5.基金项目
衡水市科技计划基金资助项目(2021014078Z) （2021014078Z）
