中国临床药理学杂志2024，Vol.40Issue(14)：2124-2128,5.DOI:10.13699/j.cnki.1001-6821.2024.14.025
丙泊酚注射液在成年全麻患者中的群体药代动力学研究
Research on population pharmacokinetics of propofol injection in adult patients under general anesthesia
摘要
Abstract
Objective To quantitatively assess the influence of various factors on the pharmacokinetic parameters of propofol and to develop a propofol population pharmacokinetic model tailored for Chinese patients.Methods Thirty patients scheduled for selective abdominal surgeries received an anesthesia dose of propofol at 2.0 mg·kg-1.The concentration of propofol in collected venous blood samples was measured using liquid chromatography-tandem mass spectrometry.Polymorphisms in metabolizing enzyme genes were detected through Sanger sequencing technology.Pharmacokinetic parameters were computed,and models were constructed and evaluated using Phoenix Winnonlin software.Results Through software analysis,the drug's in vivo process was best described by a three-compartment model.The population mean values for the central compartment clearance rate(CL),shallow peripheral compartment clearance rate(Q2),deep peripheral compartment clearance rate(Q3),central compartment volume of distribution(V),shallow peripheral compartment volume of distribution(V2),and deep peripheral compartment volume of distribution(V3)were 1.71 L·min-1,1.31 L·min-1,1.51 L·min-1,5.92 L,19.86 L and 99.06 L,respectively.Body weight was identified as a significant covariate affecting CL and V,and was incorporated into the model.Conclusion The evaluation of the final model demonstrates its substantial predictive capability,offering directional guidance for the clinical administration of propofol.关键词
丙泊酚/群体药代动力学/个体化给药/基因多态性Key words
propofol/population pharmacokinetics/individual administration/gene polymorphism分类
医药卫生引用本文复制引用
李金霞,古安城,袁福淼,李偲,邓海军,许重远..丙泊酚注射液在成年全麻患者中的群体药代动力学研究[J].中国临床药理学杂志,2024,40(14):2124-2128,5.基金项目
南方医科大学南方医院临床研究专项基金资助项目(2019CR015) （2019CR015）
