中国临床药理学杂志2024，Vol.40Issue(14)：2148-2152,5.DOI:10.13699/j.cnki.1001-6821.2024.14.030
肿瘤微环境中NLRP3炎症小体对乳腺癌转移的研究现状
Research status on the role of NLRP3 inflammasome in tumor micro-environment on breast cancer metastasis
摘要
Abstract
The expression level of NOD-like receptors(NLRP3)inflammasome is significantly elevated in breast cancer tissues,and a high level of NLRP3 inflammasomes is closely associated with breast cancer metastasis.Activation of NLRP3 inflammasome can induce the release of inflammatory factors into the tumor microenvironment(TME).These inflammatory factors,by signaling to cancer cells,reshape the TME to promote tumor growth and invasion,ultimately facilitating the process of epithelial-mesenchymal transition.This equips cancer cells with the ability to establish distant metastases and increase the formation of metastatic lesions.This review addresses the current research status and prospects of NLRP3 inflammasomes in the breast cancer TME and their role in breast cancer metastasis.The goal is to provide new insights for the study of breast cancer metastasis mechanisms and treatment strategies.关键词
乳腺癌/肿瘤转移/NOD样受体热蛋白结构域相关蛋白3炎症小体/肿瘤微环境Key words
breast cancer/tumor metastasis/NOD-like receptor thermal protein domain associated protein 3 inflammasome/tumor micro-environment分类
医药卫生引用本文复制引用
华林晔,罗弘杉,林秀莲,林丽美,夏伯候,李亚梅..肿瘤微环境中NLRP3炎症小体对乳腺癌转移的研究现状[J].中国临床药理学杂志,2024,40(14):2148-2152,5.基金项目
国家级大学生创新创业训练计划基金资助项目(202210541136) （202210541136）
湖南省教育厅科研项目优秀青年基金资助项目(23B0383) （23B0383）
湖南中医药大学校级基金资助项目(2020XJJJ011) （2020XJJJ011）
