中国临床药学杂志2024，Vol.33Issue(3)：168-175,8.DOI:10.19577/j.1007-4406.2024.03.002
ω-3多聚不饱和脂肪酸类药物影响维持性血液透析患者微炎症反应的Meta分析
Meta-analysis of the effects of ω-3 polyunsaturated fatty acids on microinflammatory responses in maintenance hemodialysis patients
摘要
Abstract
AIM To investigate ω-3 polyunsaturated fatty acids(ω-3 PUFAs)on the micro inflammatory response in maintenance hemodialysis patients.METHODS Databases such as PubMed,Web of Science,and Cochrane Library were retrieved for randomized controlled trials(RCTs)from January 2011 to December 2023.A Meta-analysis was performed using Review Manager 5.4 software.RESULTS A total of 9 RCTs were included.In term of reducing C-reactive protein in patients undergoing maintenance hemodialysis,there was a statistically significant difference between theω-3 PUFAs treatment group and the placebo control group[MD=-2.73,95％CI(-4.18,-1.29),Z=3.72,P=0.000 2].There was no statistically significant difference in reducing interleukin-6(IL-6)[MD=-13.97,95％CI(-21.58,-6.36),Z=3.60,P=0.22].The difference in tumor necrosis factor-α(TNF-α)levels between 2 groups was statistically significant[MD=-9.37,95％CI(-14.46,-4.28),Z=3.61,P=0.000 3].CONCLUSION In patients on maintenance hemodialysis,ω-3 PUFAs can significantly improve the microinflammatory response.关键词
ω-3多聚不饱和脂肪酸/维持性血液透析/微炎症反应/Meta分析Key words
ω-3 polyunsaturated fatty acids/maintenance of hemodialysis/microinflammatory reaction/Meta-analysis引用本文复制引用
王诗涵,王顺,李媛媛,陈海霞,杨文君..ω-3多聚不饱和脂肪酸类药物影响维持性血液透析患者微炎症反应的Meta分析[J].中国临床药学杂志,2024,33(3):168-175,8.基金项目
临床专科人才专业能力创新应用科研项目(编号RCLX2315094) （编号RCLX2315094）
国家自然科学基金(编号81960132) （编号81960132）
