中国临床药学杂志2024，Vol.33Issue(4)：284-288,5.DOI:10.19577/j.1007-4406.2024.04.010
醋酸亮丙瑞林联合孕三烯酮对子宫内膜异位症术后患者的疗效及免疫炎症水平的影响
Efficacy and impact on immune-inflammatory levels of leuprorelin acetate combined with gestrinone in postoperative patients with endometriosis
林伟宏 1李鲁宏 1朱思远1
作者信息
- 1. 福建医科大学附属第二医院妇产科,泉州 362000
- 折叠
摘要
Abstract
AIM To investigate the efficacy and impact on immune function of leuprorelin acetate combined with gestrinone in postoperative patients with endometriosis.METHODS From January 2020 to June 2022,152 patients with endometriosis were randomly divided into observation group and control group,with 76 cases in each group.All patients underwent laparoscopic endometriosis resection under general anesthesia.Patients in the control group were treated with leuprorelin injection after operation,while patients in the observation group were treated with leuprorelin combined with gestrinone postoperatively,with a follow-up after 6 months of treatment.The serum levels of estradiol(E2),luteinizing hormone(LH),follicle-stimulating hormone(FSH),interleukin-2(IL-2),interleukin-6(IL-6)and interleukin-10(IL-10)in 2 groups before and after surgery were measured.The efficacy,the incidence of adverse events and the cost of postoperative treatment were evaluated in 2 groups.RESULTS There was no significant difference in serum E2,LH and FSH levels between 2 groups 6 months after surgery(P＞0.05).The levels of IL-4 and IL-6 decreased significantly,and the level of IL-2 increased significantly in both groups after surgery compared to before treatment(P＜0.05).The changes in the observation group were more obvious than those in the control group(P＜0.05).There was no significant difference in the total effective rate between 2 groups(P＞0.05).The incidence of adverse events in the observation group was lower than that in the control group(P＜0.05),and the treatment cost for 6 months after surgery in the observation group was lower than that in the control group(P＜0.05).CONCLUSION Leuprorelin acetate combined with gestrinone can improve postoperative inflammation levels in patients with endometriosis,and reduce the incidence of adverse events and the cost of postoperative treatment,which has a good prospect for clinical application.关键词
醋酸亮丙瑞林/孕三烯酮/子宫内膜异位症Key words
leuprorelin acetate/gestrinone/endometriosis引用本文复制引用
林伟宏,李鲁宏,朱思远..醋酸亮丙瑞林联合孕三烯酮对子宫内膜异位症术后患者的疗效及免疫炎症水平的影响[J].中国临床药学杂志,2024,33(4):284-288,5.
