中国免疫学杂志2024，Vol.40Issue(7)：1355-1358,4.DOI:10.3969/j.issn.1000-484X.2024.07.002
IL-39在K562细胞中的作用及机制研究
Role and mechanism of IL-39 in K562 cells
摘要
Abstract
Objective:To explore the role and mechanism of IL-39 in K562 cells.Methods:The expressions of IL-39R and STAT1/STAT3 in K562 cells were detected via qRT-PCR;the protein levels of phospho-STAT1/STAT3 and STAT1/STAT3 in K562 cells were detected by Western blot;the mRNA regulated by IL-39 in K562 cells was predicted by RNA sequencing.Results:rIL-39 significantly promoted the expression of IL-39R in K562 cells;IL-39 affected K562 cells through STAT1 pathway;IL-39 significantly regulated the expression of mRNA in K562 cells,thus potentially affecting a series of biological processes.Conclusion:IL-39 can directly act on K562 cells,alter gene transcriptional expression and inhibit tumor growth through the STAT1 pathway.IL-39 may similarly modulate gene expression profile in human leukemia cells.关键词
IL-12/IL-39/K562细胞/白血病Key words
IL-12/IL-39/K562 cells/Leukemia分类
医药卫生引用本文复制引用
吕康康,徐明珠,胡博,刘跃均..IL-39在K562细胞中的作用及机制研究[J].中国免疫学杂志,2024,40(7):1355-1358,4.基金项目
国家自然科学基金青年基金项目(81500146) （81500146）
江苏省自然科学基金青年基金项目(BK20150356) （BK20150356）
国家血液系统疾病临床医学研究中心转化研究课题(2020WSC05). （2020WSC05）
