中国免疫学杂志2024，Vol.40Issue(7)：1359-1363,5.DOI:10.3969/j.issn.1000-484X.2024.07.003
全反式维甲酸对肝纤维化氧化应激损伤自然杀伤细胞的保护作用
Protective effect of all-trans retinoic acid on natural killer cells damaged by oxidative stress in liver fibrosis
摘要
Abstract
Objective:To investigate the protective effect of all-trans retinoic acid(ATRA)on the function of NK cells dam-aged by oxidative stress in liver fibrosis.Methods:Mouse model with liver injury was established by carbon tetrachloride(CCl4),biochemical and pathological assays were used to evaluate the degree of liver injury and fibrosis in mice,and changes of NK cells and oxidative stress injury in liver tissue of mice were observed.In vitro,NK92 cell lines damaged by H2O2 oxidative stress were evaluated the protective effect of ATRA.Results:Liver inflammation and fibrosis were suppressed and liver function was improved in CCl4 model mice by ATRA treatment.ATRA could increase SOD activity and GSH content in liver tissue,which promoted the proportion and num-ber of hepatic NK cells.ATRA could protect NK cells from oxidative damage and apoptosis induced by H2O2 in vitro.Conclusion:ATRA can ameliorate liver injury and fibrosis induced by CCl4,which may be related to the inhibition of oxidative stress on NK cells.关键词
全反式维甲酸/肝纤维化/氧化应激/自然杀伤细胞Key words
ATRA/Liver fibrosis/Oxidative stress/NK cells分类
医药卫生引用本文复制引用
平大冰,齐婧姝,孙鑫,黄恺,彭渊,刘成海..全反式维甲酸对肝纤维化氧化应激损伤自然杀伤细胞的保护作用[J].中国免疫学杂志,2024,40(7):1359-1363,5.基金项目
国家自然科学基金(81730109,81874363,82174057) （81730109,81874363,82174057）
上海中医药大学预算内项目(2021LK081) （2021LK081）
上海市科学技术委员会启明星计划扬帆专项(22YF1449300). （22YF1449300）
