中国免疫学杂志2024，Vol.40Issue(7)：1519-1524,6.DOI:10.3969/j.issn.1000-484X.2024.07.030
基于类器官的炎症性肠病免疫机制研究进展
Research progress on immune mechanism of inflammatory bowel disease based on organoid technology
摘要
Abstract
Inflammatory bowel disease(IBD),mainly containing Crohn's disease(CD)and ulcerative colitis(UC),is a kind of chronic idiopathic disease.The dysregulated mucosal immune response of IBD has been shown to be an important feature of disease progression.Its pathogenesis is characterized by the abnormal function of innate and specific immune associated with mucosal barrier,immune cells,cytokines and microbial homeostasis.Intestinal 3D organoids give rise to all types of cells of intestinal epithelium,pro-viding a promising model for simulating the original immune microenvironment of IBD in vitro.After briefly introducing the method of constructing an organoid model for IBD,this article reviews the progress of immune mechanism and immunotherapy of IBD under the organoid model.关键词
炎症性肠病/类器官/黏膜免疫/免疫机制Key words
Inflammatory bowel disease/Organoid/Mucosal immunity/Immune mechanism分类
医药卫生引用本文复制引用
陈园,黄骞,嵇武..基于类器官的炎症性肠病免疫机制研究进展[J].中国免疫学杂志,2024,40(7):1519-1524,6.基金项目
国家自然科学基金(82070579) （82070579）
江苏省333高层次人才培养工程(2016-Ⅱ-463) （2016-Ⅱ-463）
江苏省基础研究计划项目(BK20171329). （BK20171329）
