中国免疫学杂志2024，Vol.40Issue(7)：1525-1535,11.DOI:10.3969/j.issn.1000-484X.2024.07.031
泛素化参与自噬调节固有免疫应答的研究进展
Research progress of ubiquitination involved in autophagy in regulating innate immune response
摘要
Abstract
Innate immune response is the first line of immune defense in our body against invaded pathogens.After receive pathogen stimulation,immune cells synthesize abundant type Ⅰ interferons(IFNs)through activating three different signaling path-ways to establish strong antiviral immune response.Mounting evidences have revealed that selective autophagy participates in the regu-lation of innate type Ⅰ IFN response and prevents the excessive activation of immune responses.E3 ubiquitin ligases transfer different type of polyubiquitin chains to some key signaling proteins,and trigger the selective degradation of these proteins through autophago-some-lysosome pathway.Therefore,autophagy and E3 ubiquitin ligases integrate the spatiotemporal regulation of innate type Ⅰ IFN response.In this review,we summarized current data elucidating the critical role of autophagy and E3 ubiquitin ligases in the regula-tion of innate immune response.关键词
泛素化/自噬/固有免疫/Ⅰ型干扰素Key words
Ubiquitination/Autophagy/Innate immunity/Type Ⅰ interferon分类
医药卫生引用本文复制引用
蔡依廷,陈玮..泛素化参与自噬调节固有免疫应答的研究进展[J].中国免疫学杂志,2024,40(7):1525-1535,11.基金项目
浙江省自然科学基金(LY17C080003). （LY17C080003）
