中国免疫学杂志2024，Vol.40Issue(7)：1542-1547,6.DOI:10.3969/j.issn.1000-484X.2024.07.033
小胶质细胞-神经元双向作用相关调节分子
Regulatory molecules related with microglia-neuron two-way interaction
摘要
Abstract
As resident immune cells of central nervous system(CNS),microglia play a key role in immune surveillance and tissue repair.They can be activated by various types of pathological factors to form M1 or M2 phenotype,which mediates neuroinflam-mation or neuroprotective effects.At the same time,when the homeostasis of the microenvironment in which the neuron is located is broken,"signal"molecules are also released to induce microglial activation through ligand-receptor binding.Therefore,the regulation of microglia-neuron connection is of great significance for treatment of nervous system diseases.This article reviews the signaling mole-cules involved in the two-way interaction between microglial cells and neurons,and elucidates the immune mechanisms of microglia-neuron,thus providing a basis for targeted treatment of CNS diseases related to microglia activation.关键词
小胶质细胞/神经元/双向作用/调节分子Key words
Microglia/Neurons/Two-way interaction/Regulatory molecules分类
医药卫生引用本文复制引用
高娟,苏刚,张振昶,吴琼慧,陈玮,王满侠..小胶质细胞-神经元双向作用相关调节分子[J].中国免疫学杂志,2024,40(7):1542-1547,6.基金项目
国家自然科学基金面上项目(31870335) （31870335）
甘肃省科技计划国际合作项目(20YF8WA087) （20YF8WA087）
甘肃省国际合作基地项目(甘科外[2017]2号-33) （甘科外[2017]2号-33）
甘肃省科技厅自然科学基金(20JR5RA344) （20JR5RA344）
江苏省科技重大专项协作项目(BA2016036) （BA2016036）
兰州市科技发展指导性计划项目(2019-ZD-51) （2019-ZD-51）
兰州大学第二医院萃英科技创新计划项目(CY2018-MS06) （CY2018-MS06）
兰州大学第二医院萃英研究生指导教师培育计划项目(201802). （201802）
