中国普通外科杂志2024，Vol.33Issue(6)：1012-1017,6.DOI:10.7659/j.issn.1005-6947.2024.06.017
影响分化型甲状腺癌术后促甲状腺激素抑制治疗疗效因素的研究进展
Factors influencing the efficacy of thyrotropin suppression therapy after surgery for differentiated thyroid cancer:a review of research progress
摘要
Abstract
Differentiated thyroid cancer(DTC)is the most common type of thyroid cancer,accounting for over 94％of cases.Currently,the main treatments include radical surgical resection,selective radioiodine(131I)therapy,and thyroid-stimulating hormone(TSH)suppression therapy,with generally good overall prognosis.TSH can bind to TSH receptors expressed by DTC cells,stimulating their growth.Therefore,TSH suppression therapy is a crucial step in reducing the risk of tumor recurrence in DTC patients after surgery,and it has been clearly recommended by multiple guidelines both at home and abroad.However,in clinical practice,some patients still find it difficult to achieve the TSH suppression therapy goals,requiring repeated adjustments of the treatment dose to reach the desired targets.During the treatment process,patients may experience discomfort such as fatigue,drowsiness,or palpitations.This article mainly summarizes the factors influencing the efficacy of TSH suppression therapy after DTC surgery,aiming to help clinicians provide better postoperative TSH suppression treatment and follow-up management for DTC patients,thereby improving their quality of life,extending long-term survival,and reducing postoperative recurrence rates of DTC.关键词
甲状腺肿瘤/治疗/促甲状腺激素/预后/综述Key words
Thyroid Neoplasms/ther/Thyroid Stimulating Hormone/Prognosis/Review分类
医药卫生引用本文复制引用
张淼,许丹晴,周力,丁金旺,彭友..影响分化型甲状腺癌术后促甲状腺激素抑制治疗疗效因素的研究进展[J].中国普通外科杂志,2024,33(6):1012-1017,6.基金项目
浙江省基础公益研究基金资助项目(LGF22H070008) （LGF22H070008）
浙江省医药卫生科技基金资助项目(2021KY850,2022KY675) （2021KY850,2022KY675）
浙江省杭州市医药卫生科技基金资助项目(0020191087). （0020191087）
