中国输血杂志2024，Vol.37Issue(7)：748-753,6.DOI:10.13303/j.cjbt.issn.1004-549x.2024.07.005
治疗性血浆置换发生过敏反应的危险因素分析
Risk factors of allergic reactions caused by therapeutic plasma exchange:a single-center analysis
李玲玲 1朱晓君 1林洁 1庄远 1仇学得 1权香 1何宗忠 1江颖 1于洋1
作者信息
- 1. 解放军总医院第一医学中心 输血医学科,北京 100853
- 折叠
摘要
Abstract
Objective To review the occurrence of allergic reactions during therapeutic plasma exchange(TPE)and to explore the risk factors of TPE allergic reactions.Methods The clinical data of 929 patients treated with TPE using plasma components by the Department of Transfusion Medicine in our medical center from 2018 to 2023 were collected.The influen-cing factors of allergic reactions were analyzed by univariate analysis,and the independent risk factors of allergic reactions were analyzed by logistic multivariate regression analysis.Results A total of 4 071 TPEs were performed in 929 patients.A-mong them,198 patients(21.31%)experienced 349 times(8.57%)of allergic reactions,with the incidence of gradeⅠ,Ⅱ and Ⅲ allergic reactions of 16.33%,81.38%and 2.29%,respectively,and no deaths.The univariate analysis showed that the patient′s age,allergy history,diagnosis of immune-related diseases,ICU admission,plasma consumption,total blood volume,maximum blood flow rate and combined use of albumin were related to the occurrence of allergic reactions(P＜0.05).Multivariate regression analysis showed that young patients,a history of allergy,immune-related diseases and non-ICU patients were prone to allergic reactions in TPE,but the treatment options of TPE such as substitute fluid category,plasma consumption and blood flow rate were not related to the occurrence of allergic reactions.Conclusion There are sig-nificant individual differences in the occurrence of allergic reactions for TPE,and young age,history of allergies,immune-related diseases and non-ICU patients are risk factors for allergic reactions in TPE.Identifying patients with risk factors be-fore TPE treatment and giving corresponding preventive measures can reduce the incidence of allergic reactions.关键词
治疗性血浆置换/不良反应/过敏反应Key words
therapeutic plasma exchange(TPE)/adverse reactions/allergic reactions分类
医药卫生引用本文复制引用
李玲玲,朱晓君,林洁,庄远,仇学得,权香,何宗忠,江颖,于洋..治疗性血浆置换发生过敏反应的危险因素分析[J].中国输血杂志,2024,37(7):748-753,6.
