中国输血杂志2024，Vol.37Issue(7)：761-765,5.DOI:10.13303/j.cjbt.issn.1004-549x.2024.07.007
高原人群红细胞渗透脆性研究
A survey on osmotic fragility of erythrocytes in plateau population
摘要
Abstract
Objective To study the changes in erythrocyte osmotic fragility(EOF)in patients with hypercythemia,pol-ycythemia and anemia under a high altitude environment.Methods A total of 174 outpatients,inpatients and people un-dergoing physical examination in Tibet Autonomous Region People′s Hospital in October 2020 were enrolled and divided into four groups according to hemoglobin levels:the polycythemia group(n=42),the physiologic increase group(n=48),the a-nemia group(n=29)and the healthy control group(n=55).They were compared with 67 anemia patients and 67 healthy people in the laboratory of Peking Union Medical College Hospital in the same period as the plain control group.The classic EOF test method was used to compare the results of each group′s EOF.The concentrations of NaCl solution for starting he-molysis(STH)and NaCl solution for complete hemolysis(CTH)were included,and the data were statistically analyzed by SPSS software.Results There was a significant difference in CTH between Zang and Han healthy people(P＜0.05).STH in high altitude polycythemia group(0.52)was higher than that in high altitude healthy control group(0.48)(P＜0.001).Compared with plain,the median CTH of plateau anemia group(0.36)and plateau health control group(0.36)was signifi-cantly higher than that of plain anemia group(0.28)and plain control group(0.28)(P＜0.001).Multivariate logistic regres-sion analysis showed that plateau region,female polycythemia and anemia were risk factors for STH elevation.Conclusion This study finds that the EOF increases in the plateau population and patients with polycythemia,which provides reference for studying red blood cell disorders and blood transfusion strategy in the plateau region.关键词
红细胞渗透脆性/高原/生理性红细胞增多Key words
erythrocytes osmotic fragility/plateau/polycythemia分类
医药卫生引用本文复制引用
王爱萍,拉巴卓嘎,李薇,王轩智,谭若兰,普芝,刘治娟,秦绪珍..高原人群红细胞渗透脆性研究[J].中国输血杂志,2024,37(7):761-765,5.基金项目
西藏自治区自然科学基金组团式医学援藏项目[XZ2021ZR-ZY13(Z)] （Z）
北京协和医院中央高水平医院临床科研专项(2022-PUMCH-A-059,2022-PUMCH-B-124) （2022-PUMCH-A-059,2022-PUMCH-B-124）
