血小板微粒在糖尿病肾病患者中的表达及其与肾脏损伤的关系OACSTPCD
Expression of platelet microparticles in patients with diabetic nephropathy and its relationship with renal damage
目的 探讨血小板微粒(platelet microparticles,PMPs)在糖尿病肾病(diabetic nephropathy,DN)患者中的表达水平及其与肾脏损伤的关系.方法 纳入 30 名DN患者、30 名非DN的 2 型糖尿病患者和 30 名健康对照者.采用流式细胞术检测PMPs的数量和表型,采用ELISA法检测血浆肾素、血管紧张素Ⅱ(angiotoninⅡ,AngⅡ)、血管内皮生长因子(vascular endothelial g…查看全部>>
Objective To investigate the expression levels of platelet microparticles(PMPs)in patients with diabetic nephropathy(DN)and their relationship with renal injury.Methods Thirty DN patients,30 T2DM patients without DN and 30 healthy controls were enrolled.Flow cytometry was used to detect the quantity and phenotype of PMPs,and ELISA was used to measure the levels of plasma renin,angiotensin Ⅱ(angiotoninⅡ,AngⅡ),vascular endothelial growth factor(vascular …查看全部>>
邵雯;杜彬;杜爱翠;任召祺
火箭军特色医学中心 输血科,北京 100088火箭军特色医学中心 输血科,北京 100088火箭军特色医学中心 输血科,北京 100088火箭军特色医学中心 输血科,北京 100088
基础医学
血小板微粒糖尿病肾病肾脏损伤血管紧张素系统激活内皮功能障碍
platelet microparticles(PMPs)diabetic nephropathy(DN)renal damageactivation of renin-angiotensin systemendothelial dysfunction
《中国输血杂志》 2024 (7)
779-784,6
国家卫生健康委基金项目(2021KYSHX02303)
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