中国输血杂志2024，Vol.37Issue(7)：802-806,5.DOI:10.13303/j.cjbt.issn.1004-549x.2024.07.014
海南地区无偿献血者感染性标志物核酸筛查阳性人群特征分析
Characteristics of NAT+blood donors screened for transfusion-transmitted infectious markers in Hainan
摘要
Abstract
Objective To explore the epidemiological characteristics of voluntary blood donors with enzyme-linked im-muno-sorbent assay(ELISA)negative and nucleic acid testing(NAT)positive in Hainan from 2012 to 2022,so as to pro-vide reference for developing rational blood screening strategies.Methods The screening results for transfusion-transmitted disease markers in 1 161 042 blood samples in Hainan from 2012 to 2022 were retrospectively analyzed.All samples have been measured twice by ELISA and once by NAT.Statistical methods were used to analyze the proportion of ELISA negative and NAT positive(ELISA-/NAT+)among voluntary blood donors and its relation with factors including gender,age,eth-nicity and region.Results Among the voluntary blood donors in Hainan from 2012 to 2022,the overall proportion of ELISA-/NAT+was 0.19%(2 151/1 161 042),and the difference was statistically significant(P＜0.05).The ELISA-/NAT+rate in hepatitis B virus(HBV)DNA,hepatitis C virus(HCV)RNA,human immunodeficiency virus(HIV)RNA and non-discriminating reactive(NDR)was 0.10%,0.000 3%,0.000 4%and 0.09%respectively.The ELISA-/NAT+rate of voluntary blood donors varied among different age groups and gradually increased with age(P＜0.05).The ELISA-/NAT+rate of male donors(0.22%,1 729/795 032)was significantly higher than that of female donors(0.12%,422/366 010,P＜0.05).The ELISA-/NAT+rate of Han blood donors was significantly lower than that of Li and Miao blood donors(P＜0.05).The ELISA-/NAT+rate was the highest of 0.32%(301/94 046)in the eastern region,followed by 0.30%(341/113 783)in western region,and 0.16%in both southern and northern region,which also presented a significant difference(P＜0.05).Conclusion The ELISA-/NAT+rate of voluntary blood donors in Hainan fluctuated from 2012 to 2022,which was related to factors such as age,gender,ethnicity and region.关键词
ELISA-/NAT+/无偿献血者/人群特征/海南地区Key words
ELISA-/NAT+/voluntary blood donors/population characteristics/Hainan分类
医药卫生引用本文复制引用
张用丽,韩慧..海南地区无偿献血者感染性标志物核酸筛查阳性人群特征分析[J].中国输血杂志,2024,37(7):802-806,5.基金项目
海南省自然科学基金面上项目(820MS160) （820MS160）
