中国比较医学杂志2024，Vol.34Issue(6)：106-112,7.DOI:10.3969/j.issn.1671-7856.2024.06.014
线粒体质量控制系统在脓毒性心肌病发病中的研究进展
Progress of research into mitochondrial mass control system's role in the pathogenesis of septic cardiomyopathy
摘要
Abstract
Septic cardiomyopathy(SIC)is an organ dysfunction frequently observed in sepsis and characterized by high mortality and poor prognosis.Understanding the complex pathogenesis of SIC and developing effective therapeutic tools are critical issues that require attention.Previous studies have demonstrated the significant role of mitochondrial dysfunction in the development of SIC.In the presence of SIC,and the mitochondrial dysfunction that result,the aberrant regulation of the mitochondrial quality control system(MQC)can exacerbate cardiomyocyte injury.Recent studies have demonstrated that the MQC maintains the dynamics of mitochondrial homeostasis through its regulation of mitochondrial biogenesis,fusion/fission,and autophagy.This article provides an overview of the role of MQC in SIC pathogenesis,reviews the latest studies in the field,and analyzes MQC's potential as a therapeutic target.关键词
脓毒症心肌病/线粒体质量控制系统/线粒体生物发生/线粒体融合和裂变/线粒体自噬Key words
septic cardiomyopathy/mitochondrial quality control system/mitochondrial biogenesis/mitochondrial fusion and fission/mitochondrial autophagy分类
医药卫生引用本文复制引用
解有成,肖曙芳,林雪梅,陈顺,徐进,王菲..线粒体质量控制系统在脓毒性心肌病发病中的研究进展[J].中国比较医学杂志,2024,34(6):106-112,7.基金项目
国家自然科学基金(82160367) （82160367）
甘肃省自然科学基金(21JR1RA181) （21JR1RA181）
甘肃省卫生健康行业健康计划项目(GSWSKY2022-49). （GSWSKY2022-49）
