中国比较医学杂志2024，Vol.34Issue(6)：113-118,6.DOI:10.3969/j.issn.1671-7856.2024.06.015
Notch信号通路在肝纤维化中的研究进展
Progress of research into Notch signaling pathway in liver fibrosis
摘要
Abstract
Liver fibrosis is a key pathological process in the progression of chronic liver disease to cirrhosis and even liver cancer.The occurrence of liver fibrosis is a highly integrated and dynamic pathological process result ing from the interactions of many cells and cytokines.The Notch signaling pathway is an evolutionarily conserved intercellular signal transduction mechanism that plays important roles in regulating the development and tissue renewal of multicellular animals.Multiple studies have shown that Notch signal transduction participates in the formation of liver fibrosis in a variety of ways.Therefore,this paper reviews the role of Notch signaling in cells involved in the formation of liver fibrosis to explain the function of this signaling pathway in liver fibrosis.关键词
Notch信号通路/肝纤维化/综述Key words
Notch signaling pathway/liver fibrosis/review分类
医药卫生引用本文复制引用
纪少秀,张恒耀,张媛,文莉..Notch信号通路在肝纤维化中的研究进展[J].中国比较医学杂志,2024,34(6):113-118,6.基金项目
国家自然科学基金(82104569) （82104569）
四川省科技厅应用基础研究项目(2021YJ0253) （2021YJ0253）
成都中医药大学"十四五""基础增厚"行动计划团队(242022007). （242022007）
