中国比较医学杂志2024，Vol.34Issue(6)：127-134,8.DOI:10.3969/j.issn.1671-7856.2024.06.017
铁死亡在脓毒症急性肺损伤中的研究进展
Research progress in the role of ferroptosis in sepsis-associated acute lung injury
摘要
Abstract
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection with an extremely high mortality rate,and it is the main risk factor for acute lung injury(ALI).However,the pathophysiology and pathogenesis of sepsis-associated ALI are not fully understood,and effective drugs are extremely limited.Therefore,it is urgent that we explore the pathogenesis of sepsis-associated ALI and attempt to discover effective intervention measures to improve the prognosis of sepsis-associated ALI patients.In recent years,ferroptosis has been considered closely related to the pathological and physiological processes of sepsis-associated ALI,and inhibiting related cell ferroptosis can effectively slow down the occurrence and development of the disease.In this paper,therapeutic strategies targeting ferroptosis in related cells are reviewed to provide a reference for future research on ferroptosis in sepsis-associated ALI and provide a new perspective on potential treatments.关键词
脓毒症/急性肺损伤/铁死亡Key words
sepsis/acute lung injury/ferroptosis分类
医药卫生引用本文复制引用
史阳琳,杨建雅,常晴晴,王倩倩,王明航,李素云..铁死亡在脓毒症急性肺损伤中的研究进展[J].中国比较医学杂志,2024,34(6):127-134,8.基金项目
国家自然科学基金(82374416) （82374416）
河南省卫生健康委国家中医临床研究基地科研专项(2022JDZX124) （2022JDZX124）
国家中医药管理局中医药防治新型冠状病毒感染应急专项(2023ZYLCYJ02-14) （2023ZYLCYJ02-14）
河南省中医药科学研究专项(2023ZYZD03) （2023ZYZD03）
河南省呼吸疾病临床医学研究中心资助(豫科(2020)158号). （豫科(2020）
