中国比较医学杂志2024，Vol.34Issue(6)：144-150,7.DOI:10.3969/j.issn.1671-7856.2024.06.019
基于线粒体质量控制探讨运动对骨骼肌萎缩的研究进展
Research progress in the benefits of exercise in muscular atrophy based on mitochondrial quality control
摘要
Abstract
Skeletal muscle wasting refers to a loss of skeletal muscle mass and function.Mitochondrial quality control(MQC)is the basis by which normal physiological mitochondrial function is maintained and mainly involves the regulation of mitochondrial biogenesis,mitochondrial dynamics(fission/fusion),and mitophagy.MQC maintains muscle homeostasis by regulating the relative stability of mitochondrial shape,quantity,and quality.As an economical and effective treatment for muscular atrophy,exercise interventions are widely used,but the relationship between exercise intervention and MQC is not clear.This paper discusses the role of mitochondrial biogenesis,mitochondrial dynamics,and mitophagy in skeletal muscle atrophy and related molecular targets.We thoroughly analyze the mechanisms by which MQC-mediated exercise can improve the skeletal muscle atrophy caused by aging,disuse,and cancer cachexia in order to provide theoretical guidance for intervention.关键词
肌萎缩/运动/线粒体生物生成/线粒体动力学/线粒体自噬Key words
muscle atrophy/exercise/mitochondrial biogenesis/mitochondrial dynamics/mitophagy分类
医药卫生引用本文复制引用
郭孝静,王艳,张立,裴飞,张博,秦欢,王淑瑾,李晓童..基于线粒体质量控制探讨运动对骨骼肌萎缩的研究进展[J].中国比较医学杂志,2024,34(6):144-150,7.基金项目
国家自然科学基金(82274623,81973926). （82274623,81973926）
