中国现代医学杂志2024，Vol.34Issue(13)：1-6,6.DOI:10.3969/j.issn.1005-8982.2024.13.001
血清NLRP3、IL-18水平与多囊卵巢综合征患者不孕的关系
Correlation study of serum NLRP3 and IL-18 levels with infertility in patients with polycystic ovary syndrome
摘要
Abstract
Objective To investigate the correlation between serum levels of NOD-like receptor protein 3(NLRP3)and interleukin-18(IL-18)and infertility in patients with polycystic ovary syndrome(PCOS).Methods From March 2020 to March 2023,a total of 294 infertile patients with PCOS were selected as the study group from Nankai University Affiliated Obstetrics and Gynecology Hospital and Tianjin First Central Hospital.Additionally,280 infertile patients due to tubal abnormalities,endometriosis,and other causes were selected as the control group.Clinical data of the two groups were compared.Serum NLRP3 and IL-18 levels were measured using enzyme-linked immunosorbent assay(ELISA).Multivariate stepwise logistic regression analysis was used to identify factors influencing infertility in PCOS patients.Receiver operating characteristic(ROC)curve analysis was employed to evaluate the predictive value of serum NLRP3 and IL-18 levels for infertility in PCOS patients.Results There were no significant differences between the two groups in terms of age,duration of infertility,smoking,alcohol consumption,systolic blood pressure,diastolic blood pressure,total cholesterol,high-density lipoprotein,low-density lipoprotein,and follicle-stimulating hormone(P＞0.05).The study group had higher body mass index(BMI),triglycerides,homeostasis model assessment of insulin resistance(HOMA-IR),luteinizing hormone,and transferrin levels compared to the control group(P＜0.05).Serum levels of NLRP3 and IL-18 were significantly higher in the study group(P＜0.05).Multivariate stepwise logistic regression analysis indicated that serum NLRP3[(O)R=4.293(95％CI:1.941,9.495)],serum IL-18[(O)R=4.104(95％CI:1.770,9.515)],HOMA-IR[(O)R=3.404(95％CI:1.477,7.846)],and BMI[(O)R=3.391(95％CI:1.542,7.455)]were risk factors for infertility in PCOS patients(P＜0.05).ROC curve analysis showed that the areas under the curve(AUC)for predicting infertility in PCOS patients using serum IL-18,NLRP3,and their combination were 0.748(95％CI:0.698,0.801),0.844(95％CI:0.796,0.894),and 0.905(95％CI:0.855,0.950),respectively.The sensitivities of serum IL-18,NLRP3,and their combination for predicting infertility in PCOS patients were 66.32％(95％CI:0.572,0.746),79.39％(95％CI:0.713,0.857),and 88.53％(95％CI:0.844,0.934),respectively.The specificities were 70.68％(95％CI:0.623,0.799),73.28％(95％CI:0.656,0.827),and 86.32％(95％CI:0.830,0.908),respectively.Conclusion Elevated serum levels of NLRP3 and IL-18 are closely associated with infertility in PCOS patients and can serve as biological markers for predicting infertility in this population.关键词
多囊卵巢综合征/不孕症/NOD样受体蛋白3/白细胞介素-18/相关性研究Key words
polycystic ovary syndrome/infertility/NOD-like receptor protein 3/interleukin-18/correlation study分类
医药卫生引用本文复制引用
朱松楠,张红媛,李艳..血清NLRP3、IL-18水平与多囊卵巢综合征患者不孕的关系[J].中国现代医学杂志,2024,34(13):1-6,6.基金项目
天津市科技计划项目(No:S21DYYBA2331) （No:S21DYYBA2331）
