中国现代医学杂志2024，Vol.34Issue(13)：57-62,6.DOI:10.3969/j.issn.1005-8982.2024.13.008
Tfh/Tfr细胞免疫平衡在血液恶性肿瘤中的研究进展
Research progress on Tfh/Tfr cell immune balance in hematologic malignancies
摘要
Abstract
Follicular helper T cells(Tfh)and follicular regulatory T cells(Tfr)are newly discovered CD4+T cell subsets with opposite effects.In the process of germinal center and humoral immunity,Tfh cells assist in the production of antibodies,while Tfr cells inhibit the function of Tfh cells and B cells.The immune balance of Tfh/Tfr cells plays an important role in the formation of germinal center,the proliferation and differentiation of B cells and the production of antibodies.Tfh/Tfr cell balance is closely related to autoimmune diseases,solid tumors and some hematological diseases,but its role in malignant hematological tumors is not clear.This paper reviews the latest research progress of Tfh/Tfr cell immune balance in malignant hematological tumors,which points out a new direction for the pathogenesis and immunotherapy of malignant hematological tumors.关键词
骨髓增生异常综合征/淋巴瘤/多发性骨髓瘤/白血病/滤泡辅助性T细胞/滤泡调节性T细胞Key words
myelodysplastic syndromes/lymphoma/multiple myeloma/leukemia/follicular helper T cells/follicular regulatory T cells分类
医药卫生引用本文复制引用
张冉冉,张瑞,曲建华..Tfh/Tfr细胞免疫平衡在血液恶性肿瘤中的研究进展[J].中国现代医学杂志,2024,34(13):57-62,6.基金项目
国家自然科学基金(No:82160034) （No:82160034）
新疆维吾尔自治区天山创新团队项目(No:2022D14008) （No:2022D14008）
