PI3K/Akt信号通路调控急性髓系白血病机制及中医药治疗研究进展OACSTPCD

AAcute myeloid leukemia(AML)is a highly aggressive hematologic malignancy characterized by rapid proliferation of immature myeloid leukemia cells.With the rapid development of modern methods such as gene sequencing and proteomics,the molecular mechanism of the pathogenesis and prognosis of AML has gradually deepened,but it has not broken the current situation of high recurrence rate,immune escape,minimal residue,large side effects of radiotherapy and chemotherapy,and heavy financial and psychological burden on patients'families.Phosphatidylinositol-3 kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)is the most classic oncogenic pathway,and many studies have developed many drugs to deal with AML through this pathway.In recent years,traditional Chinese medicine has been widely concerned and recognized because of its multi-level,multi-target,and low adverse reaction advantages,and has played an important role in the field of cancer treatment.Therefore,this study reviewed the relationship between PI3K/Akt signaling pathway and AML,and found that TCM monomers and TCM compounds can mediate PI3K/Akt signaling pathway,inhibit tumor cell proliferation,migration,invasion and angiogenesis,and then affect the pathological development of AML.