中国现代医学杂志2024，Vol.34Issue(13)：80-84,5.DOI:10.3969/j.issn.1005-8982.2024.13.011
奥美拉唑联合阿托品对急性胃炎患者血清胃泌素和丙二醛水平的影响
Effects of omeprazole combined with atropine on serum gastrin and malondialdehyde levels in patients with acute gastritis
摘要
Abstract
Objective To explore the effects of omeprazole combined with atropine on serum gastrin and malondialdehyde levels in patients with acute gastritis.Method This study included 107 patients with acute gastritis treated in our hospital from January 2020 to January 2023.Divided into a control group(53 cases,treated with omeprazole combined with scopolamine)and an observation group(54 cases,treated with omeprazole combined with atropine),the treatment lasted for 14 days.Evaluate the clinical treatment efficacy,serum gastrin levels,malondialdehyde levels,serum pepsinogen I levels,drug tolerance,score of digestive symptoms,inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]in two groups of patients,C-reactive protein(CRP)levels were measured,and the incidence of adverse reactions was recorded for both groups of patients.Result The total effective rate of the observation group was higher than that of the control group(P＜0.05).The difference before and after malondialdehyde treatment,and the difference before and after serum pepsinogen I treatment also showed that the difference was statistically significant(P＜0.05),and the difference in these indicators before and after treatment in the observation group was lower than that in the control group.In the comparison of drug tolerance,did not show statistical significance(P＞0.05);In addition,the difference in the scores of adverse symptoms such as belching,nausea and vomiting,early satiety,upper abdominal burning sensation,and upper abdominal distension before and after treatment between the two groups was statistically significant(P＜0.05).The difference in the scores of various digestive symptoms before and after treatment in the observation group was higher than that in the control group(P＜0.05).The observation group had IL-6 and TNF-α before and after treatment.The difference between CRP and the control group was higher(P＜0.05).The incidence of adverse reactions between the two groups was compared,did not show statistical significance(P＞0.05).Conclusion The combination of omeprazole and atropine has a significant reducing effect on serum gastrin and malondialdehyde levels in patients with acute gastritis,and can effectively improve clinical symptoms and reduce levels of inflammatory factors.It shows good therapeutic effect on regulating serum indicators in patients with acute gastritis and may become a new strategy for treating acute gastritis.关键词
急性胃炎/奥美拉唑/阿托品/血清胃泌素/丙二醛Key words
acute gastritis/omeprazole/atropine/serum gastrin/malondialdehyde分类
医药卫生引用本文复制引用
李婷婷,张晓旭,曲乐,李锋林..奥美拉唑联合阿托品对急性胃炎患者血清胃泌素和丙二醛水平的影响[J].中国现代医学杂志,2024,34(13):80-84,5.基金项目
黑龙江省自然科学基金(No:LH2021H050) （No:LH2021H050）
