中国现代医学杂志2024，Vol.34Issue(13)：85-90,6.DOI:10.3969/j.issn.1005-8982.2024.13.012
乳腺癌患者血清NLR、CA199水平与诺丁汉预后指数的关系研究
Study on the relationship between serum NLR,CA199 levels and nottingham prognostic index in breast cancer patients
摘要
Abstract
Objective To investigate the correlation between serum neutrophil-to-lymphocyte ratio(NLR)and carbohydrate antigen 199(CA199)levels with the Nottingham Prognostic Index(NPI)in breast cancer patients,in order to assess the applicative value of these biomarkers in the prognosis of breast cancer.Methods A retrospective analysis was conducted on the clinical data of 72 breast cancer patients diagnosed at Huai'an Traditional Chinese Medicine Hospital from June 2017 to June 2021.Patients were divided into three groups based on the NPI index,and the correlation between serum NLR and CA199 levels with NPI scores was compared.Additionally,a 24 month follow-up analysis was performed to identify risk factors leading to poor prognosis.The predictive value of serum NLR and CA199 levels for poor prognosis in breast cancer was analyzed using the receiver operating characteristic(ROC)curve.Results Significant differences in serum NLR and CA199 levels were found among the three groups(P＜0.05).The high-risk group had higher serum NLR and CA199 levels compared to the low-risk and medium-risk groups(P＜0.05).Compared to the good prognosis group,the poor prognosis group had statistically significant differences in TNM stage,lymph node metastasis,NPI,NLR,and CA199 levels(P＜0.05).Multivariate logistic regression analysis showed that advanced TNM stage,lymph node metastasis,high NPI,high NLR,and high CA199 levels were independent risk factors for poor prognosis in breast cancer patients(P＜0.05).The area under the ROC curve(AUC)for the combined prediction of poor prognosis using serum NLR,CA199 levels,and NPI was 0.922(95％CI:0.812,0.999),with a sensitivity of 86.7％(95％CI:0.695,1.000)and specificity of 98.2％(95％CI:0.948,1.000).Conclusion There is a significant correlation between serum NLR and CA199 levels with NPI scores in breast cancer patients,indicating their utility as tools for assessing the prognosis of breast cancer.关键词
乳腺癌/NLR/CA199/诺丁汉预后指数/关系Key words
breast cancer/neutrophil-to-lymphocyte ratio/CA199/nottingham prognostic index/correlation分类
医药卫生引用本文复制引用
蔡秋妍,凌雨,张晓洁,陈璟..乳腺癌患者血清NLR、CA199水平与诺丁汉预后指数的关系研究[J].中国现代医学杂志,2024,34(13):85-90,6.基金项目
江苏省自然科学基金(No:BK20221424) （No:BK20221424）
