中国现代医学杂志2024，Vol.34Issue(14)：15-19,5.DOI:10.3969/j.issn.1005-8982.2024.14.003
布地格福与茚达特罗格隆溴铵治疗慢性阻塞性肺疾病的疗效比较
Comparison of the efficacy of budesonide/glycopyrrolate/formoterol fumarate and indacaterol/glycopyrrolate in the treatment of chronic obstructive pulmonary disease
摘要
Abstract
Objective To compare the efficacy of budesonide/glycopyrrolate/formoterol fumarate and indacaterol/glycopyrrolate in the treatment of chronic obstructive pulmonary disease(COPD).Methods A total of 100 patients with COPD admitted to our hospital from January 2022 to December 2022 were selected,and were divided into the control group and the study group by the random number table method,with 50 cases in each group.The control group was treated with budesonide/glycopyrrolate/formoterol fumarate inhalation aerosol,and the study group was given indacaterol/glycopyrrolate inhalation powder.The therapeutic effects were evaluated after continuous treatment for 12 weeks.The lung function,clinical efficacy,airway remodeling indexes,inflammatory factors,immune function and adverse drug reactions were compared between the two groups.Results The differences of forced vital capacity(FVC),peak expiratory flow(PEF)and forced expiratory volume in one second(FEV1)/FVC before and after the treatment were not significantly different between the two groups(P＞0.05).There was no significant difference in the overall effective rate between the two groups(P＞0.05).The differences of the ratio of airway wall thickness to outer diameter and the wall area percentage before and after treatment were not significantly different between the two groups(P＞0.05).The differences of the levels of C-reactive protein,serum amyloid A and interleukin-17 before and after the treatment were not significantly different between the two groups(P＞0.05).The difference of the CD4+/CD8+ratio before and after the treatment was not different between the two groups(P＞0.05).There was no significant difference in the overall incidence of adverse reactions between the two groups(P＞0.05).Conclusion The efficacy of budesonide/glycopyrrolate/formoterol fumarate is comparable to that of indacaterol/glycopyrrolate in the treatment of COPD.Both of them could significantly enhance the lung function,inhibit inflammatory responses,improve the immune function,and prevent airway remodeling with a good safety profile.关键词
慢性阻塞性肺疾病/布地格福/茚达特罗格隆溴铵/疗效Key words
chronic obstructive pulmonary disease/budesonide/glycopyrrolate/formoterol fumarate/indacaterol/glycopyrrolate/effect分类
医药卫生引用本文复制引用
高丽,刘斌,王友梅..布地格福与茚达特罗格隆溴铵治疗慢性阻塞性肺疾病的疗效比较[J].中国现代医学杂志,2024,34(14):15-19,5.基金项目
安徽省自然科学基金(No:2008085MB32) （No:2008085MB32）
