中国现代医学杂志2024，Vol.34Issue(14)：46-51,6.DOI:10.3969/j.issn.1005-8982.2024.14.007
慢性阻塞性肺疾病与Hedgehog信号通路关系的研究进展
Advances in the relationship between chronic obstructive pulmonary disease and the Hedgehog signaling pathway
摘要
Abstract
Chronic obstructive pulmonary disease(COPD)is a disease characterized by airflow obstruction,with high prevalence and mortality rates.The Hedgehog(HH)signaling pathway plays a key role in regulating and controlling the morphology and development of tissues and the damage repair.It has been found that COPD is closely related to the HH signaling pathway,and that some important signaling molecules in this pathway can ameliorate inflammation and fibrosis when airway impairment induces inflammatory responses.An in-depth understanding of the roles of the HH signaling pathway in the development of COPD will facilitate further discovery and research into therapeutic targets for this disease.By introducing the HH pathway and critical signaling molecules affecting the lung development and regulating inflammatory responses in COPD,this review is of great significance for gaining insights into the pathophysiological processes of COPD,and provides a theoretical basis for the treatment of COPD by targeting the HH signaling pathway.关键词
慢性阻塞性肺疾病/Hedgehog信号通路/气道炎症/作用机制Key words
chronic obstructive pulmonary disease/Hedgehog signaling pathway/airway inflammation/mechanism of action分类
医药卫生引用本文复制引用
裴文辉,王云超,汪娆娆,杨震,王新华..慢性阻塞性肺疾病与Hedgehog信号通路关系的研究进展[J].中国现代医学杂志,2024,34(14):46-51,6.基金项目
国家重点研发计划(No:2017YFC0907202) （No:2017YFC0907202）
中央引导地方科技发展资金项目(No:22ZY1QA003) （No:22ZY1QA003）
2022年甘肃省高等学校产业支撑计划项目(No:2022CYZC-53) （No:2022CYZC-53）
2023年甘肃中医药大学研究生创新创业项目 （）
