中国畜牧兽医2024，Vol.51Issue(7)：2880-2889,10.DOI:10.16431/j.cnki.1671-7236.2024.07.014
黄酮类化合物调控Keap1-Nrf2/ARE信号通路的抗氧化机制及其在畜禽生产中应用的研究进展
Research Progress on Antioxidant Mechanism of Flavonoids Regulating the Keap1-Nrf2/ARE Signaling Pathway and Its Application in Livestock and Poultry
鄂晓迪 1赵晓南 1赵金标 2胡友军1
作者信息
- 1. 广东酸能生物科技有限公司,清远 511500||广东酸动力生物科技有限公司,清远 511500
- 2. 中国农业大学动物科技学院,北京 100193
- 折叠
摘要
Abstract
Flavonoids are polyphenolic compounds that are widely found in natural plants and have strong antioxidant capabilities.In recent years,more and more studies have proved that flavonoids are beneficial to livestock production as feed additives.Kelch-like ECH-associating protein 1-nuclear factor erythroid 2 related factor 2/antioxidant response element(Keap1-Nrf2/ARE)is a key signaling pathway that enhances the body's antioxidant capacity and is involved in resisting damage from external oxidative stress.Flavonoids mainly regulate the Keap1-Nrf2/ARE pathway,activate the expression of upstream and downstream key factors,activate the activity of antioxidant enzymes,improve the body's antioxidant capacity,and thus achieve the improvement of animal growth performance,reproductive performance,and immune system.In this article the molecular structure of Keap1-Nrf2/ARE and its antioxidant mechanism,as well as the regulation of Keap1-Nrf2/ARE signaling pathway by flavonoids and their application in animal production were reviewed.The aim of this paper is to provide reference for the further development and application of flavonoids as feed additives.关键词
Kelch样环氧氯丙烷相关蛋白1(Keap1)/核因子E2相关因子2(Nrf2)/黄酮类化合物/抗氧化机制Key words
Kelch-like ECH-associating protein 1(Keap1)/nuclear factor erythroid 2 related factor 2(Nrf2)/flavonoids/antioxidant mechanism分类
农业科技引用本文复制引用
鄂晓迪,赵晓南,赵金标,胡友军..黄酮类化合物调控Keap1-Nrf2/ARE信号通路的抗氧化机制及其在畜禽生产中应用的研究进展[J].中国畜牧兽医,2024,51(7):2880-2889,10.
