中国畜牧兽医2024，Vol.51Issue(7)：3086-3099,14.DOI:10.16431/j.cnki.1671-7236.2024.07.033
猪源病毒细胞毒性T淋巴细胞表位研究进展
Advances in Cytotoxic T Lymphocyte Epitopes of Porcine Viruses
摘要
Abstract
The major histocompatibility complex(MHC)class Ⅰ molecules,also known as swine leukocyte antigen(SLA)class Ⅰ molecules,play an important role in antigen presentation,organ transplantation,immune response and regulation.Cytotoxic T lymphocyte(CTL)epitopes are linear peptides that bind and present SLA-Ⅰ molecules after antigen processing by antigen-presenting cells.With high specificity,CTL epitopes play a key role in antigen recognition and presentation and cellular immunity against viral infection.CTL epitopes can stimulate CTLs to play the role of cell killing,which is mainly manifested as killing virus.The author reviewed the current status of CTL epitopes of several important porcine viruses,such as Foot-and-mouth disease virus,African swine fever virus and Porcine reproductive and respiratory syndrome virus,and analyzed the binding motif characteristics of SLA-Ⅰ and CTL epitopes by bioinformatics,in order to provide a reference for studying CTL epitopes derived from porcine viruses and designing the epitope vaccine in future.关键词
细胞毒性T淋巴细胞(CTL)表位/猪口蹄疫病毒/非洲猪瘟病毒/猪繁殖与呼吸综合征病毒Key words
cytotoxic T lymphocyte(CTL)epitopes/Porcine foot-and-mouth disease virus/African swine fever virus/Porcine reproductive and respiratory syndrome virus分类
农业科技引用本文复制引用
鲜钰涵,高凤山,冯宏盛,高永宇,李海洋,杨思宇,桑辰君,曹玉蝶,唐越,李子彬..猪源病毒细胞毒性T淋巴细胞表位研究进展[J].中国畜牧兽医,2024,51(7):3086-3099,14.基金项目
国家自然科学基金项目(32273022) （32273022）
大连大学创新团队项目(202011015) （202011015）
