中国药房2024，Vol.35Issue(14)：1748-1752,5.DOI:10.6039/j.issn.1001-0408.2024.14.13
腹腔镜术后戈舍瑞林联合戊酸雌二醇治疗育龄期子宫内膜异位症的临床观察
Clinical observation of goserelin combined with estradiol valerate in the treatment of endometriosis in patients of childbearing age after laparoscopic surgery
摘要
Abstract
OBJECTIVE To observe the efficacy and safety of goserelin combined with estradiol valerate in the treatment of endometriosis(EMs)in patients of childbearing age after laparoscopic surgery.METHODS The clinical data of 144 patients with EMs of childbearing age who underwent laparoscopic surgery in our hospital from January 2020 to December 2022 were collected retrospectively,and those patients were divided into control group(70 cases)and combination group(74 cases)based on different postoperative medication regimens.Control group was given Acetate goserelin sustained-release implant on the 1st to 5th day of their first menstrual cycle after laparoscopic surgery,while combination group was additionally given Estradiol valerate tablets on the basis of control group.The short-term and long-term efficacy of 2 groups were observed;preoperative and postoperative pain scores,ovarian reserve function,and the incidence of adverse reactions were all recorded in 2 groups.RESULTS There was no statistically significant difference in short-term total effective rate,1-year postoperative recurrence rate and the incidence of decreased libido,vaginal dryness,gastrointestinal reactions,rash,or arrhythmia between two groups(P＞0.05).The natural pregnancy rate of combination group was significantly higher than control group at 1 year after surgery,while the incidence of early miscarriage,hot flashes and sweating,emotional fluctuations,insomnia and fatigue,joint muscle pain,dizziness and headache were significantly lower than control group(P＜0.05).However,at 6 months after surgery,pain scores and the levels of anti-Müllerian hormone,follicle stimulating hormone,luteinizing hormone,estradiol of both groups were significantly lower than before surgery in the same group,while the number of antral follicle count was significantly higher than before surgery in the same group;the levels of anti-Müllerian hormone,luteinizing hormone,estradiol,and the number of antral follicles in the combination group were significantly higher than control group,while pain score and follicle stimulating hormone level were significantly lower than control group(P＜0.05).CONCLUSIONS The combination of goserelin and estradiol valerate after laparoscopic surgery has a significant therapeutic effect and good safety in the treatment of EMs of childbearing age.关键词
子宫内膜异位症/腹腔镜手术/戈舍瑞林/戊酸雌二醇/妊娠率/卵巢储备功能/安全性Key words
endometriosis/laparoscopic surgery/goserelin/estradiol valerate/pregnancy rate/ovarian reserve function/safety分类
药学引用本文复制引用
王慧玲,马宁,乔磊,杨君,文政芳..腹腔镜术后戈舍瑞林联合戊酸雌二醇治疗育龄期子宫内膜异位症的临床观察[J].中国药房,2024,35(14):1748-1752,5.基金项目
河南省医学科技攻关计划项目(No.LHGJ20220616) （No.LHGJ20220616）
