静脉用药复溶剂生成系统及溶媒配伍禁忌规则库的建立及应用OA北大核心CSTPCD
Establishment and application of intravenous drug resolvent generation system and solvent incompatibility rules library
目的 规范注射用无菌粉末复溶剂及静脉用药溶媒的使用,保障临床用药安全.方法 我院审方药师团队通过制定需用灭菌注射用水溶解的药品目录和静脉用药溶媒配伍禁忌表,在医院信息系统中搭建静脉用药复溶剂生成系统及静脉用药溶媒配伍禁忌规则库.统计分析我院2023年1-4月(静脉用药溶媒配伍禁忌规则库实施前)和2023年5-8月(实施后)审核干预的不合理医嘱,比较实施前后我院溶媒选择不合理医嘱数量、拦截率及药师对溶媒选择不合理医嘱干预成功率的变化情况.结果 我院静脉用药溶媒配伍禁忌规则库实施前,共发现溶媒选择不合理医嘱5 229组,其中严重不合理医嘱有1 204组,拦截率为23.03%,审方药师对其的干预成功率为15.90%;实施后,共发现溶媒选择不合理医嘱3 258组,其中严重不合理医嘱有1 148组,拦截率为35.24%,药师对其的干预成功率为24.83%,均显著高于实施前(P＜0.01或P＜0.001).结论 我院通过建立并应用静脉用药复溶剂生成系统及静脉用药溶媒配伍禁忌规则库,显著提高了对溶媒选择不合理医嘱的拦截率和药师干预成功率,有助于保障患者用药安全.
OBJECTIVE To standardize the use of sterile powder for injection redissolution solvent and intravenous drugs diluent solvent,and ensure the safety of clinical drug use.METHODS The intravenous drug resolvent generation system and the intravenous drug solvent incompatibility rules library were constructed and operated by prescription-checking pharmacist team in our hospital by formulating a list of intravenous drugs needed to be dissolved with sterilized water for injection and a contraindication list of intravenous solvent compatibility.The unreasonable medical orders reviewed and intervened in our hospital from January to April 2023(before the implementation of the intravenous drug solvent incompatibility rules library)and from May to August 2023(after the implementation)were analyzed statistically to compare the number of unreasonable solvent selection orders,interception rate,and the success rate of pharmacists'interventions for unreasonable solvent selection orders before and after the implementation.RESULTS Before the implementation of the solvent incompatibility rules library,a total of 5 229 groups of medical orders with unreasonable solvent selection in our hospital were identified,among which there were 1 204 groups of seriously unreasonable medical orders,with interception rate of 23.03%and the success rate of pharmacists'intervention of 15.90%.After the implementation of the solvent incompatibility rules library,the total number of medical orders with unreasonable solvent selection was 3 258 groups,among which there were 1 148 groups of seriously unreasonable medical orders,with interception rate of 35.24%and success rate of pharmacists'intervention of 24.83%,being significantly higher than before implementation(P＜0.01 or P＜0.001).CONCLUSIONS The establishment and application of the intravenous drug resolvent generation system and the solvent incompatibility rules library can significantly increase the interception rate of unreasonable solvent selection orders and the success rate of pharmacists'interventions,and ensure the safety of clinical drug use.
黄莺;李培芳;杜德才;方明;刘圣
中国科学技术大学附属第一医院(安徽省立医院)药学部,合肥 230001
药学
注射用无菌粉末复溶剂溶媒配伍禁忌
sterile powder for injectionredissolution solventsolventincompatibility
《中国药房》 2024 (014)
1786-1789 / 4
安徽省教育厅高等学校省级质量工程项目(No.2020jyxm2319)
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