中国药房2024，Vol.35Issue(14)：1795-1800,6.DOI:10.6039/j.issn.1001-0408.2024.14.22
中药通过PI3K/Akt信号通路干预肾间质纤维化的研究进展
Research progress on the intervention of traditional Chinese medicine in renal interstitial fibrosis based on PI3K/Akt signaling pathway
摘要
Abstract
Renal interstitial fibrosis(RIF)is the main pathological manifestation of chronic kidney disease.Due to the complexity of the mechanism,there is no specific treatment for RIF in clinical practice.The abnormal activation of the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)signaling pathway and the activation of downstream target genes are key drivers of RIF induction and progression.Traditional Chinese medicine has the characteristics of precise efficacy and minimal toxic side effects,and the occurrence and development of RIF can be regulated by multiple targets and mutual coordination.This review focuses on the PI3K/Akt signaling pathway and summarizes the potential targets and regulatory mechanisms of traditional Chinese medicine in the treatment of RIF.It is found that various effective ingredients(such as sinomenine,mangiferin,coumarin derivates from Hydrangea paniculata,etc.)and formulas(such as Fushengong decoction,Qi-Bang-Yi-Shen formula,etc.)of traditional Chinese medicine can inhibit fibroblast proliferation,improve inflammation and oxidative stress,maintain mitochondrial stability,and slow down ferroptosis through this pathway,thereby delaying the occurrence and progression of RIF.关键词
中药/PI3K/Akt信号通路/肾间质纤维化/作用机制Key words
traditional Chinese medicine/PI3K/Akt signaling pathway/renal interstitial fibrosis/action of mechanism分类
药学引用本文复制引用
李雪,张云龙,宋子毅,张柱江,杨超,任天娇,贾淋珍..中药通过PI3K/Akt信号通路干预肾间质纤维化的研究进展[J].中国药房,2024,35(14):1795-1800,6.基金项目
国家级大学生创新创业训练计划项目(No.202311230035) （No.202311230035）
黑龙江省自然科学基金项目(No.LH2021H120) （No.LH2021H120）
齐齐哈尔医学科学院青年博士项目(No.QMSI2022B-03) （No.QMSI2022B-03）
齐齐哈尔医学科学院博士滚动支持项目(No.QMSI2023E-02) （No.QMSI2023E-02）
齐齐哈尔医学科学院重点培育项目(No.2024-ZDPY-002) （No.2024-ZDPY-002）
