中国药理学通报2024，Vol.40Issue(8)：1401-1407,7.DOI:10.12360/CPB202301061
前动力蛋白受体2在心脑血管及神经退行性疾病治疗中的研究进展
Research progress of PK2 in treatment of cardio-cerebrovascular and neurodegenerative diseases
摘要
Abstract
Cardio-cerebrovascular and neurodegenerative diseases are diseases of high-incidence diseases among middle-aged and elderly people,with high disability and mortality rates,which se-riously threaten human health.PK2 is a newly discovered secre-ted protein that plays an important role in many physiological and pathological processes by binding to its receptor PKR1 or 2.Numerous studies related to PK2/PKRs have shown that this sig-naling pathway also plays a very important role in the occurrence and development of cardiovascular,cerebrovascular and neuro-degenerative diseases,and through exploring the connection be-tween them,PK2/PKRs may become a new target for the clini-cal treatment of these diseases.关键词
前动力蛋白受体/心血管疾病/脑血管疾病/神经退行性疾病/作用机制Key words
PK2/cardiovascular diseases/cerebrovascular dis-eases/neurodegenerative diseases/mechanism of action分类
医药卫生引用本文复制引用
李峰,付建华,张路,姚明江..前动力蛋白受体2在心脑血管及神经退行性疾病治疗中的研究进展[J].中国药理学通报,2024,40(8):1401-1407,7.基金项目
中国中医科学院科技创新工程重大攻关项目(No C12021A01305,C12021A00912) （No C12021A01305,C12021A00912）
国家中医药管理局中医药创新团队及人才支持计划项目(No ZYYCXTD-C-202007) （No ZYYCXTD-C-202007）
