中国药理学通报2024，Vol.40Issue(8)：1407-1412,6.DOI:10.12360/CPB202312035
缺血性脑卒中后小胶质细胞胞葬作用的研究进展
Review of microglial efferocytosis in ischemic stroke
摘要
Abstract
Once ischemic stroke occurs,severely insufficient blood supply causes massive neuronal apoptosis and necrosis,leading to the release of damage-associated molecular patterns(DAMPs)that exacerbate neuroinflammation and worsen brain damage.As the resident efferocytes in central nervous system,microglia possess the capability to phagocytose and eliminate ap-optotic cells by efferocytosis before necrosis occurs,thereby mit-igating the release of DAMPs and the accumulation of cellular debris.This process is crucial for neuroinflammation reduction and neurorestoration.Hence,a comprehensive understanding of the regulatory mechanism of microglial efferocytosis post-ische-mia,as well as its impact on neuroinflammation and cerebral damage,has the potential to advance diagnostic and therapeutic approaches for ischemic stroke.Here,we outline the molecular mechanisms and signaling pathways involved in microglial effero-cytosis following ischemic stroke,and summarize the research progress on drugs targeting microglial efferocytosis to enhance stroke prognosis.关键词
小胶质细胞/胞葬作用/缺血性脑卒中/细胞凋亡/神经炎症/药物治疗Key words
microglia/efferocytosis/ischemic stroke/apopto-sis/neuroinflammation/pharmacotherapy分类
医药卫生引用本文复制引用
范平龙,赖华清,张钊,楚世峰,陈乃宏..缺血性脑卒中后小胶质细胞胞葬作用的研究进展[J].中国药理学通报,2024,40(8):1407-1412,6.基金项目
国家自然科学基金资助项目(No 82130109,82074044,U21A20410) （No 82130109,82074044,U21A20410）
CAMS 医学科学创新基金(No 2021-I2M-1-020) （No 2021-I2M-1-020）
