中国药理学通报2024，Vol.40Issue(8)：1424-1429,6.DOI:10.12360/CPB202307066
多巴胺奖赏系统参与抑郁环路机制及中医药干预研究思考与展望
Reflection and prospect on mechanism of dopamine reward system involvement in depression loop and traditional Chinese medicine intervention research
摘要
Abstract
In the process of seeking new strategies to improve the efficacy of antidepressants,traditional Chinese medicine inter-vention has gradually revealed its unique prevention and treat-ment advantages.The dopamine reward system is closely in-volved in the pathological occurrence and development of depres-sion.Currently,research has mostly focused on the functional mechanism of a specific nucleus in the dopamine reward system,and there is less research focused on the functional mechanism of the neural circuit.In the current micro research on reward cir-cuits,the association between abnormal reward circuits and neg-ative emotions such as anxiety and depression has been widely recognized.Traditional Chinese medicine intervention can exert antidepressant effects by influencing reward circuits.This article provides a review on the loop mechanism of dopamine reward system involvement in depression and research on traditional Chinese medicine intervention.关键词
抑郁症/奖赏系统/神经环路/多巴胺/腹侧背盖区/伏隔核Key words
depression/reward system/neural circuit/dopa-mine/ventral dorsal tegmental area/nucleus accumbens分类
医药卫生引用本文复制引用
李卓娴,周流畅,叶丽宏,邓迪,赵金兰,史亚飞,张荣..多巴胺奖赏系统参与抑郁环路机制及中医药干预研究思考与展望[J].中国药理学通报,2024,40(8):1424-1429,6.基金项目
国家自然科学基金资助项目(No 82074219,82274226,82274443,82104557,82104623) （No 82074219,82274226,82274443,82104557,82104623）
广东省基础与应用基础研究基金(No 2021A1515012572,2022A1515010230) （No 2021A1515012572,2022A1515010230）
广州市科技计划(No 202201011267) （No 202201011267）
广州中医药大学学科协同创新团队重点项目(No 2021xk29) （No 2021xk29）
广东省科技计划项目(No 2023B1212060063) （No 2023B1212060063）
