中国药理学与毒理学杂志2024，Vol.38Issue(7)：533-541,9.DOI:10.3867/j.issn.1000-3002.2024.07.007
线粒体自噬在乳腺癌发生发展中的作用及其调控机制
Research progress in roles and mechanism of mitophagy in breast cancer
摘要
Abstract
Mitophagy is a process by which cells selectively eliminate damaged or dysfunctional mitochondria through the autophagy-lysosomal pathway under the regulation of mitophagy-related proteins to maintain mitochondrial quality and cellular homeostasis,and it is closely related to the occurrence and development of a variety of tumors.Increasing studies have shown that mitophagy plays a dual role in breast cancer progression.① Mitophagy promotes breast cancer cell survival and invasion by triggering energy metabolic reprogramming,reducing ROS accumulation and maintaining mitochondrial homeostasis.②Mitophagy leads to death or apoptosis of breast cancer cells by attenuating inflamma-tory responses and triggering mitochondrial damage.The relevant mechanisms include①PTEN induced kinase 1,PINK1(PINK1)/Parkin pathway;② autophagy receptor-associated protein pathway(including BNIP3,BNIP3L and FUNDC1);③ mitochondrial division pathway.This review summarizes the role and mechanism of mitophagy in the hopes of providing reference for research and treatment of breast cancer.关键词
乳腺癌/线粒体自噬/PINK1/Parkin/自噬相关受体蛋白/自噬调节因子/化疗耐药Key words
breast cancer/mitophagy/PINK1/Parkin/autophagy receptor protein/autophagy regu-lator/chemotherapy resistance分类
医药卫生引用本文复制引用
丁烨,魏佳乐,熊阳..线粒体自噬在乳腺癌发生发展中的作用及其调控机制[J].中国药理学与毒理学杂志,2024,38(7):533-541,9.基金项目
国家自然科学基金(82174095) （82174095）
国家级大学生创新创业训练计划(202310344051) （202310344051）
浙江省自然科学基金(LZ22H290001) （LZ22H290001）
浙江省中医药科技计划(2023ZL362) National Natural Science Foundation of China(82174095) （2023ZL362）
Undergraduate Training Programs for Innovation and Entrepreneurship(202310344051) （202310344051）
Natural Science Foundation of Zhejiang Province of China(LZ22H290001) （LZ22H290001）
and Zhejiang Province Traditional Chinese Medicine Science and Technology Project(2023ZL362) （2023ZL362）
