中国药物经济学2024，Vol.19Issue(6)：29-32,48,5.DOI:10.12010/j.issn.1673-5846.2024.06.005
某院围术期预防应用质子泵抑制剂合理性及成本-效果分析
Rationality and Cost-effectiveness Analysis of Perioperative Prophylactic Application for Proton Pump Inhibitors in A Hospital
摘要
Abstract
Objective To investigate the current situation of perioperative prophylactic use of proton pump inhibitors(PPIs)in a hospital,analyze the rationality of its use,explore the cost-effectiveness of different drug regimens,and evaluate the pharmacoeconomics.Methods The archival medical records of the surgical department of Karamay Hospital of Integrated Chinese and Western Medicine from January to December 2022 were selected to screen perioperative prophylactic application of PPIs,summarize the use situation and evaluate the rationality of drug use.Groups A,B and C were divided into three groups according to drug selection.Group A was prophylaxis with omeprazole sodium for injection,group B was prophylaxis with lansoprazole sodium for injection,and group C was prophylaxis with Pantoprazole sodium for injection.The incidence of prevention of stress ulcer(SU),incidence of adverse drug reactions and cost-effectiveness of different PPIs were compared.Results A total of 387 medical records were used for perioperative prophylactic use of PPIs,including 272 patients with indications and 115 patients with drugs without reference.There was no significant difference in the incidence of SU,the incidence of adverse drug reactions and the effective rate of SU prevention among 3 groups(P＞0.05).In group A,B and C,the C/E of group A was the lowest,followed by group C,and group B was the highest.Compared with group A,the cost of prophylactic PPIs in group B increased by 14.72 yuan for every 1 unit increase in efficacy.In group C,the cost of prophylactic PPIs increased by 6.96 yuan for each additional unit of efficacy.Conclusion The prophylactic application of PPIs during perioperative period in our hospital is unreasonable,and corresponding measures should be taken to improve it.Omeprazole is an effective and economical scheme to prevent SU.关键词
质子泵抑制剂/围术期/预防用药/合理性/成本-效果分析Key words
Proton pump inhibitors/Perioperative period/Preventive medication/Rationality/Cost-effectiveness analysis分类
医药卫生引用本文复制引用
施洋,谭雪,陈振东,彭磊,周娜,柳俊宇,易兵荣,樊登峰..某院围术期预防应用质子泵抑制剂合理性及成本-效果分析[J].中国药物经济学,2024,19(6):29-32,48,5.基金项目
克拉玛依市首届科技创新人才培养项目(克科发[2023]1号) （克科发[2023]1号）
克拉玛依市创新环境建设计划(软科学)项目(2024hjrkx0040) （软科学）
克拉玛依市中西医结合医院(市人民医院)院级科研项目(Kzxy2023003) （市人民医院）
